Evidence map›Paper›PMID 41467595›Full record

ArticleJournal of natural products2026

CURE-ating the Substrate Scope and Functional Residues of Nonheme Iron(II) α-Ketoglutarate-Dependent Hydroxylase BesE.

Austin R Hopiavuori, Beau S Andre, Emely D Avalos, Surina L Beal, George R Beck, Charles J Choi, Elizabeth M Dolzhansky, Michelle X Du, Isabella S Gallardo, Cyrus J Ghorbani and 4 more

Abstract read
In one paragraph

Article in Journal of natural products, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Austin R HopiavuoriDepartment of Chemistry and Biochemistry, University of California Santa Cruz, Santa Cruz, California 95064, United States.ORCID 0000-0002-7093-7558
Beau S AndreDepartment of Chemistry and Biochemistry, University of California Santa Cruz, Santa Cruz, California 95064, United States.
Emely D AvalosDepartment of Chemistry and Biochemistry, University of California Santa Cruz, Santa Cruz, California 95064, United States.
Surina L BealDepartment of Chemistry and Biochemistry, University of California Santa Cruz, Santa Cruz, California 95064, United States.
George R BeckDepartment of Chemistry and Biochemistry, University of California Santa Cruz, Santa Cruz, California 95064, United States.
Charles J ChoiDepartment of Chemistry and Biochemistry, University of California Santa Cruz, Santa Cruz, California 95064, United States.ORCID 0009-0001-5095-6356
Elizabeth M DolzhanskyDepartment of Chemistry and Biochemistry, University of California Santa Cruz, Santa Cruz, California 95064, United States.
Michelle X DuDepartment of Chemistry and Biochemistry, University of California Santa Cruz, Santa Cruz, California 95064, United States.
Isabella S GallardoDepartment of Chemistry and Biochemistry, University of California Santa Cruz, Santa Cruz, California 95064, United States.ORCID 0009-0005-8878-662X
Cyrus J GhorbaniDepartment of Chemistry and Biochemistry, University of California Santa Cruz, Santa Cruz, California 95064, United States.
Kyle M HinagaDepartment of Chemistry and Biochemistry, University of California Santa Cruz, Santa Cruz, California 95064, United States.
Analynn T NguyenDepartment of Chemistry and Biochemistry, University of California Santa Cruz, Santa Cruz, California 95064, United States.
Edward H T PhamDepartment of Chemistry and Biochemistry, University of California Santa Cruz, Santa Cruz, California 95064, United States.
Shaun M K McKinnieDepartment of Chemistry and Biochemistry, University of California Santa Cruz, Santa Cruz, California 95064, United States.ORCID 0000-0001-6776-6455

Funding

Identification, characterization, and application of bacterial site-specific vanadium-dependent haloperoxidase enzymesR35GM147235 · NIGMS · UNIVERSITY OF CALIFORNIA SANTA CRUZ · PI Shaun Mitchell Kirk McKinnie · 2022 to 2026
$1.9M
Development of a high throughput platform for screening directed evolution librariesR21GM148870 · NIGMS · UNIVERSITY OF CALIFORNIA SANTA CRUZ · PI SANCHEZ, LAURA MARGARET · 2023 to 2024
$430k
NIGMS NIH HHS R21 GM148870NIGMS NIH HHS R35 GM147235
6 · The paper itself

Abstract

Nonheme iron(II) α-ketoglutarate-dependent dioxygenases (Fe/αKGs) play important roles in functionalizing biological substrates from individual amino acids to macromolecules. BesE, a unique homologue from the actinobacterial β-ethynylserine biosynthetic pathway, catalyzes a highly selective hydroxylation on dipeptide substrate γ-l-glutamyl-l-propargylglycine (

Indexed as

Ketoglutaric AcidsMixed Function OxygenasesDipeptidesHydroxylationIronMolecular StructureSubstrate SpecificityDipeptidesIronKetoglutaric AcidsMixed Function Oxygenases

Identifiers

PMID41467595
PMCPMC13207679

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.