Evidence map›Paper›PMID 41467412›Full record

ArticleNeural regeneration research2026

Prospect in Alzheimer's disease integrative therapy targeting both amyloid-beta and tau.

Wei Zhang, Yiqun Zhou, Jiuyan Chen, Miranda Perez, Xiomara Claure, Roger M Leblanc

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neural regeneration research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Wei ZhangDepartment of Chemistry, University of Miami, Coral Gables, FL, USA.
Yiqun ZhouDepartment of Chemistry, University of Miami, Coral Gables, FL, USA.
Jiuyan ChenDepartment of Chemistry, University of Miami, Coral Gables, FL, USA.
Miranda PerezDepartment of Chemistry, University of Miami, Coral Gables, FL, USA.
Xiomara ClaureDepartment of Chemistry, University of Miami, Coral Gables, FL, USA.
Roger M LeblancDepartment of Chemistry, University of Miami, Coral Gables, FL, USA.ORCID 0000-0001-8836-8042

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Alzheimer's disease is well characterized by the buildup of amyloid-β plaques and tau protein tangles, leading to neurodegeneration and cognitive impairments. Recent prosperous Alzheimer's disease therapeutic development targeting amyloid-β validates the amyloid hypothesis. Nonetheless, the limited efficacy of single-target therapies plus as-observed synergy between amyloid-β and tau calls for a thorough understanding of Alzheimer's disease pathogenesis. Thus, this review introduces Alzheimer's disease pathogenesis, specifically focusing on the amyloid-β and tau pathologies, highlights their interconnected nature, presents personal perspectives on therapeutic and diagnostic challenges, and underscores the necessity of combined therapeutic approaches to effectively address Alzheimer's disease.

Indexed as

Alzheimer’s diseaseamyloid-βintegrative therapyinterplaymulti-target therapytau

Identifiers

PMID41467412
PMCPMC13568674

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.