Evidence map›Paper›PMID 41467344›Full record

ArticleThe Journal of clinical endocrinology and metabolism2026

Work Loss and Income Before and After Diagnosis of Addison's Disease: A Population-Based Longitudinal Study.

Stavros Stergianos, Åsa H Everhov, Jonas Söderling, Jakob Skov, Sophie Bensing

Abstract read
In one paragraph

Article in The Journal of clinical endocrinology and metabolism, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Stavros StergianosDepartment of Medicine, Solna, Division of Experimental Endocrinology, Karolinska Institutet, Stockholm SE-171 76, Sweden.ORCID 0000-0003-3476-3287
Åsa H EverhovDepartment of Medicine, Solna, Division of Clinical Epidemiology, Karolinska Institutet, Stockholm SE-171 76, Sweden.ORCID 0000-0002-0311-8894
Jonas SöderlingDepartment of Medicine, Solna, Division of Clinical Epidemiology, Karolinska Institutet, Stockholm SE-171 76, Sweden.ORCID 0000-0001-9006-2835
Jakob SkovDepartment of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm SE-171 76, Sweden.ORCID 0000-0002-3738-1367
Sophie BensingDepartment of Medicine, Solna, Division of Experimental Endocrinology, Karolinska Institutet, Stockholm SE-171 76, Sweden.ORCID 0000-0002-9193-2860

Funding

Karolinska InstitutetRegional Agreement on Medical Training and Clinical Research (ALF)Region Värmland's County Research CouncilStockholm County Council
6 · The paper itself

Abstract

contextThe effect of autoimmune Addison's disease (AAD) on work ability and income over time remains unclear.

objectiveThis work aimed to evaluate differences and temporal trends in income and lost workdays among patients with AAD before and after diagnosis, vs matched general population comparators. This nationwide, register-based cohort study was conducted in Sweden. We linked the Swedish Addison Register with national health registers to identify 716 working-age individuals (aged 20-62 years) with incident AAD 2003 to 2019 and 3271 general-population comparators matched by sex, age, county, calendar year, and education level. Annual work loss, taxable earnings, and disposable income were examined over a 10-year period around diagnosis using linear (work loss) and quantile (earnings, income) regression.

resultsPatients with AAD had significantly more work loss than comparators from 1 year before to 3 years after diagnosis, with the largest difference the year after diagnosis (mean difference: 30.5 days; 95% CI, 22.9-38.0 days). Median taxable earnings were lower in patients with AAD 1 year before (median difference: $-1107; 95% CI, $-2042 to $-173; P = .02) and 1 year after diagnosis ($-1105; 95% CI, $-2166 to $-43; P = .04). Disposable income was also reduced 1 year after diagnosis (median difference: $-1084; 95% CI, $-1813 to $-354; P = .004).

conclusionIn AAD, increased work loss and reduced earnings and income were concentrated around diagnosis, peaking in the year after. Reassuringly, both absence from work and income normalized within 4 years following diagnosis.

Indexed as

Addison DiseaseIncomeAdultFemaleHumansLongitudinal StudiesMaleMiddle AgedRegistriesSwedenYoung AdultAddison's diseasedisability pensionincomesick leavesocioeconomicswork loss

Identifiers

PMID41467344
PMCPMC13183444

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.