ArticleActa radiologica open2025
Comparison of low- and standard-dose CT-guided transthoracic core needle biopsies: Feasibility, safety, diagnostic yield, and radiation dose.
Article in Acta radiologica open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Computed tomography (CT)-guided transthoracic biopsy is essential for diagnosing pulmonary lesions but exposes patients to considerable radiation from repeated image acquisitions. With the growing emphasis on radiation safety, applying validated low-dose CT protocols to interventional procedures has become a key clinical priority. Purpose: To assess the feasibility, safety, diagnostic yield, and radiation dose of low-dose computed tomography-guided transthoracic biopsies using an 80 kVp protocol compared with standard 120 kVp protocols. Methods: A retrospective review was performed on 183 consecutive computed tomography-guided transthoracic biopsies of lung nodules or masses, including 143 procedures with the standard 120 kVp protocol and 40 procedures with a low-dose 80 kVp protocol at 30 mAs. Procedural characteristics, image quality, histopathological adequacy, radiation exposure, and complications were analyzed. Both subjective and objective image quality assessments, including signal-to-noise and contrast-to-noise ratios, and cellular analyses of specimens were compared. Results: The low-dose protocol reduced mean effective radiation dose from 5.89 ± 2.88 millisieverts to 0.19 ± 0.06 millisieverts, a 96.8% reduction. Biopsy specimen adequacy was 85% in the low-dose group versus 79% in the standard-dose group. Complication rates were comparable, 45% versus 43.4%. Subjective image quality was lower in the low-dose group, but objective signal-to-noise and contrast-to-noise ratios remained sufficient for accurate diagnosis. Conclusion: Computed tomography-guided transthoracic biopsies with an 80 kVp and 30 mAs protocol significantly reduce radiation exposure without compromising diagnostic yield or safety. This low-dose approach is a viable alternative to conventional protocols and can be adopted in routine interventional radiology practice.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.