ArticleInternational journal of cardiology. Heart & vasculature2025
The long-term prognostic value of CT coronary artery calcium score in asymptomatic patients with type 2 diabetes.
Article in International journal of cardiology. Heart & vasculature, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Highlights recently published in the International Journal of Cardiology Heart & Vasculature on sex differences in cardiovascular disease diagnosis and management.International journal of cardiology. Heart & vasculature · 2026Article
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Authors and funding
6 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Background: Coronary artery calcium scoring (CACS) may improve risk stratification of diabetics, in whom coronary artery disease (CAD) is often more diffuse and progressive. We examined the long-term value of CACS in outcome prediction of asymptomatic patients with type 2 diabetes. Methods: A population-based cohort recruited between 2006 and 2008 of type 2 diabetics aged 55-74 years, with at least one additional risk factor and no history or symptoms of CAD. The association of overall (n = 735) and individual vessel (n = 596) CACS with the occurrence of myocardial infarction (MI), ischemic stroke, or all-cause death (MACE) was assessed over a median follow-up of 17.3 years. Results: Increasing levels of CACS independently predicted MACE and its components, particularly MI, with no events of MI observed in those with zero CACS, and an adjusted hazard ratio (95 % confidence interval) of 2.31 (1.30-4.11) for MI in those with CACS > 300 compared to 1-100 Agatston units. The addition of CACS to MESA 10-year coronary heart disease risk score increased significantly the discriminatory capacity for MI [combined AUC 0.75 (0.72-0.78)]. For each additional coronary artery with any CACS, the adjusted HR for MI was 1.68 (1.34-2.10), and for MACE 1.18 (1.08-1.30), p < 0.001. The hazard for MI or MACE did not increase in proportion to the percentage of CACS localized to the left-main coronary artery. Conclusions: The predictive value of CACS in asymptomatic diabetics is retained over 17 years of follow-up, particularly for MI. The number of coronary arteries with calcified plaques may provide additional prognostic information.
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