Evidence map›Paper›PMID 41467224›Full record

ArticleInternational journal of cardiology. Heart & vasculature2025

Transcatheter tricuspid valve intervention versus optimal medical therapy alone for severe tricuspid regurgitation: an updated meta-analysis with reconstructed time-to-event data.

Ahmed Ibrahim, Laila Shalabi, Sofian Zreigh, Shrouk Ramadan, Ahmed Samir, Mohamed Adel Elsawy, Mohamed Mahmoud Fathy, Belal Mohamed Hamed, Hossam Elbenawi, Mustafa Turkmani and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of cardiology. Heart & vasculature, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Ahmed IbrahimFaculty of Medicine, Alexandria University, Alexandria, Egypt.
Laila ShalabiFaculty of Medicine, Gharyan University, Gharyan, Libya.
Sofian ZreighFaculty of Medicine, Ankara Yıldırım Beyazıt University, Ankara, Turkey.
Shrouk RamadanFaculty of Medicine, Ain Shams University, Cairo, Egypt.
Ahmed SamirFaculty of Medicine, Minia University, Minya, Egypt.
Mohamed Adel ElsawyFaculty of Medicine, Al-Azhar University, Cairo, Egypt.
Mohamed Mahmoud FathyFaculty of Medicine, Al-Azhar University, New Damietta, Egypt.
Belal Mohamed HamedFaculty of Medicine, Al-Azhar University, Cairo, Egypt.
Hossam ElbenawiDepartment of Cardiovascular Medicine, Mayo Clinic, Rochester, USA.
Mustafa TurkmaniDivision of Pulmonary and Critical Care, University of Toledo, Toledo, OH, USA.
Ahmed Y AzzamMedical Big Data Research Center, SNU Medical Research Center, Seoul National University (SNU), Seoul, South Korea.
Hani Mahmoud-ElsayedDepartment of Cardiology, Aswan Heart Center, Magdi Yacoub Foundation, Aswan, Egypt.
Islam Y ElgendyDivision of Cardiovascular Medicine, Gill Heart Institute, University of Kentucky, Lexington, KY, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Severe tricuspid regurgitation (TR) is strongly associated with high mortality and morbidity. This Methods: Electronic databases were systematically searched to identify randomized controlled trials (RCTs) and propensity score-matched observational studies comparing TTVI with OMT. The primary outcome was all-cause mortality. Summary estimates were calculated using a random-effects model. Results: Five studies (3 RCTs, 2 observational; Conclusion: Among patients with severe TR, TTVI was not statistically associated with a lower incidence of all-cause mortality but was associated with a reduced risk of HF hospitalization, significant reduction in TR severity, and improved quality of life. Future large RCTs with extended follow-up are needed to confirm these findings and identify the subset of patients who benefit the most.

Indexed as

All-cause mortalityHeart failure hospitalizationMeta-analysisOptimal medical therapySevere tricuspid regurgitationTranscatheter tricuspid valve intervention

Identifiers

PMID41467224
PMCPMC12744525

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.