ArticleJGH open : an open access journal of gastroenterology and hepatology2025
The Post-Cholecystectomy Gut Microbiota Follows a Time-Varying Change-A Pilot Study.
Article in JGH open : an open access journal of gastroenterology and hepatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed.
- Review
- Cholecystectomy-induced gut dysbiosis and its consequences: bridging animal models and clinical outcomes in narrative review.Translational gastroenterology and hepatology · 2026Review
- The Post-Cholecystectomy Gut Microbiota Follows a Time-Varying Change-A Pilot Study.JGH open : an open access journal of gastroenterology and hepatology · 2025Article
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Gut microbiota is proposed to be a key factor for post-cholecystectomy diarrhea (PCD). Long-term follow-up showed decreasing PCD over time, suggesting microbiota change is time-dependent. Our study aimed to analyze gut microbiota and PCD at different times to clarify their time-varying features. Methods: Patients aged 20-70 receiving laparoscopic cholecystectomy were recruited prospectively. Subjects with prior abdominal surgery, major systemic diseases, use of antibiotics, probiotics, or proton pump inhibitors within 1 month were excluded. Stool was analyzed at baseline (BL) and 6th, 12th month post-surgery. Microbial diversity was assessed with R phyloseq package, and differential abundance of taxonomic composition with LEfSe/metagenomeSeq. Results: Ten patients were enrolled. Bristol stool scale peaked at 1 M (3.9 → 4.5 → 3.4; Conclusions: This study showed time-varying trends of microbial diversity and composition. Larger studies are needed for further validation.
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Registered trials
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