ArticleJGH open : an open access journal of gastroenterology and hepatology2025
Causal Relationship Between Butyrate and Dyspepsia: Evidence From Two-Sample Mendelian Randomization Analysis of CSF Metabolites.
Article in JGH open : an open access journal of gastroenterology and hepatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Causal Relationship Between Butyrate and Dyspepsia: Evidence From Two-Sample Mendelian Randomization Analysis of CSF Metabolites.JGH open : an open access journal of gastroenterology and hepatology · 2025Article
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Dyspepsia is a prevalent gastrointestinal disorder with complex pathogenesis involving the gut-brain axis. While alterations in gut microbiota have been linked to dyspepsia, the role of central nervous system metabolites, particularly those in cerebrospinal fluid (CSF), remains unexplored. Objective: To investigate the potential causal relationship between CSF metabolites and dyspepsia using a two-sample Mendelian randomization (MR) approach. Methods: We conducted a two-sample MR analysis using genome-wide association study (GWAS) summary statistics. CSF metabolite data were derived from 532 individuals across two cohorts, and dyspepsia outcome data were obtained from the UK Biobank (7586 cases and 353 608 controls). Instrumental variables (SNPs) were selected based on genome-wide significance ( Results: Among 71 CSF metabolites tested, only butyrate (4:0) showed a significant inverse causal association with dyspepsia (IVW OR = 0.997, 95% CI: 0.996-0.998, Conclusions: Our study provides the first genetic evidence linking elevated CSF butyrate levels to a reduced risk of dyspepsia, highlighting a potential neuroprotective role within the gut-brain axis.
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