Evidence map›Paper›PMID 41467179›Full record

ArticleiScience2025

Efficient derivation of hiPSC-derived photoreceptor precursor cells and their neuroprotective effects in retinal degeneration.

Yuxin Du, Jingjing Cao, Lumeng Niu, Gao Tan, Jingmin Zhang, Xiaoqian Yi, Yu Li, Jun Wei, Yin Shen

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Yuxin DuEye Center, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, P.R. China.
Jingjing CaoZhongmou Therapeutics Co., Ltd., Wuhan, Hubei 430060, P.R. China.
Lumeng NiuiRegene Therapeutics Co., Ltd, Chengdu, Sichuan 610200, P.R. China.
Gao TanEye Center, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, P.R. China.
Jingmin ZhangiRegene Therapeutics Co., Ltd, Chengdu, Sichuan 610200, P.R. China.
Xiaoqian YiZhongmou Therapeutics Co., Ltd., Wuhan, Hubei 430060, P.R. China.
Yu LiEye Center, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, P.R. China.
Jun WeiiRegene Therapeutics Co., Ltd, Chengdu, Sichuan 610200, P.R. China.
Yin ShenEye Center, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, P.R. China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Retinal degenerative diseases such as retinitis pigmentosa (RP) lack effective therapies capable of restoring vision. Photoreceptor precursor cell (PPC) transplantation is a promising regenerative strategy. This study utilized the PPCs efficiently derived from human-induced pluripotent stem cell (hiPSC). The employment of AM580, a chemical compound of oxidatively stable retinoid analogs, facilitated the differentiation of hiPSCs into CRX

Indexed as

cell biologymolecular biologyneuroscience

Identifiers

PMID41467179
PMCPMC12744287

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.