ArticleiScience2025
Effects of seasonal factors on brain function: Systematic review and future perspectives.
Article in iScience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The empirical evidence for the effects of changing seasons on humans and other species has long been a subject of public and scientific curiosity. However, supporting evidence is predominantly behavioral, warranting further quantitative/mechanistic validation. Three putative mechanisms proposed here include (1) variability in photoperiod and temperature, (2) gravitational effects from varying Earth-celestial body distances, including lunar phases and eclipses, and (3) changes in geomagnetism. This systematic review (PubMed, Web of Science, and Scopus; until September'24) aims to identify studies on the effects of seasonality, gravity, and geomagnetism on brain function, establishing a baseline for the proposed hypotheses. Distinct search queries were tailored to capture the relevant literature. Behavioral and observational data support the hypotheses, with limited EEG/MRI evidence indicating potential neural correlates, although most research is cross-sectional and preliminary. Future work should employ well-powered, longitudinal, and hypothesis-driven designs to clarify the observed effects, thereby confirming or challenging competing views.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.