Evidence map›Paper›PMID 41467176›Full record

ArticleiScience2025

Development and prospective validation of a multitarget urine RNA assay for noninvasive detection of urothelial carcinoma.

Hua Xu, Shuai Wang, Dingwei Xue, Zhihui Xu, Qi Zhang, Qijun Wo, Banggao Huang, Zujie Mao, Feng Liu, Shuixin Lou and 10 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Hua XuDepartment of Urology, Fudan University Shanghai Cancer Center, Fudan University, No. 270, Dong'an Road, Xuhui District, Shanghai 200032, China.
Shuai WangUrology & Nephrology Center, Department of Urology, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, No. 158, Shangtang Road, Hangzhou 310000, China.
Dingwei XueDepartment of Urology, Sir Run Run Shaw Hospital, Zhejiang University, School of Medicine, No. 3, Qingchun East Road, Shangcheng District, Hangzhou 310000, China.
Zhihui XuUrology & Nephrology Center, Department of Urology, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, No. 158, Shangtang Road, Hangzhou 310000, China.
Qi ZhangUrology & Nephrology Center, Department of Urology, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, No. 158, Shangtang Road, Hangzhou 310000, China.
Qijun WoUrology & Nephrology Center, Department of Urology, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, No. 158, Shangtang Road, Hangzhou 310000, China.
Banggao HuangUrology & Nephrology Center, Department of Urology, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, No. 158, Shangtang Road, Hangzhou 310000, China.
Zujie MaoUrology & Nephrology Center, Department of Urology, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, No. 158, Shangtang Road, Hangzhou 310000, China.
Feng LiuUrology & Nephrology Center, Department of Urology, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, No. 158, Shangtang Road, Hangzhou 310000, China.
Shuixin LouUrology & Nephrology Center, Department of Urology, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, No. 158, Shangtang Road, Hangzhou 310000, China.
Jie YuanDepartment of Urology, Sir Run Run Shaw Hospital, Zhejiang University, School of Medicine, No. 3, Qingchun East Road, Shangcheng District, Hangzhou 310000, China.
Shibin ZhuDepartment of Urology, Sir Run Run Shaw Hospital, Zhejiang University, School of Medicine, No. 3, Qingchun East Road, Shangcheng District, Hangzhou 310000, China.
Lifeng DingDepartment of Urology, Sir Run Run Shaw Hospital, Zhejiang University, School of Medicine, No. 3, Qingchun East Road, Shangcheng District, Hangzhou 310000, China.
Yixin WoThe Canhelp Genomics Research Center, Canhelp Genomics Co., Ltd., No. 22, Xinyan Road, Linping District, Hangzhou 310000, China.
Zhengzhi LuoThe Canhelp Genomics Research Center, Canhelp Genomics Co., Ltd., No. 22, Xinyan Road, Linping District, Hangzhou 310000, China.
Jinying ChenThe Canhelp Genomics Research Center, Canhelp Genomics Co., Ltd., No. 22, Xinyan Road, Linping District, Hangzhou 310000, China.
Qinghua XuThe Canhelp Genomics Research Center, Canhelp Genomics Co., Ltd., No. 22, Xinyan Road, Linping District, Hangzhou 310000, China.
Gonghui LiDepartment of Urology, Sir Run Run Shaw Hospital, Zhejiang University, School of Medicine, No. 3, Qingchun East Road, Shangcheng District, Hangzhou 310000, China.
Xiaolong QiUrology & Nephrology Center, Department of Urology, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, No. 158, Shangtang Road, Hangzhou 310000, China.
Dingwei YeDepartment of Urology, Fudan University Shanghai Cancer Center, Fudan University, No. 270, Dong'an Road, Xuhui District, Shanghai 200032, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Accurate and noninvasive diagnosis is critical in the management of urothelial carcinoma (UC). This study develops and prospectively validates a multitarget urine RNA (mt-uRNA) test for noninvasive UC detection. The RNA panel, built using quantitative RT-PCR and support vector machine algorithms, achieved an area under the curve of 0.956 in the upgraded training set of 688 samples. In the prospective validation phase, urine samples from 752 patients in three Chinese medical centers were analyzed, and the test achieved an overall accuracy of 93.4%, with a sensitivity of 92.3% and specificity of 94.1%. This robustness was maintained across subgroups, demonstrating high sensitivity for carcinoma

Indexed as

CancerDiagnostic procedureDiagnostic technique in health technology

Identifiers

PMID41467176
PMCPMC12744290

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.