Evidence map›Paper›PMID 41467042›Full record

ArticleAmerican journal of ophthalmology case reports2026

Long-term outcome of cultured corneal endothelial cell transplantation with descemetorhexis: A 10-year follow-up study.

Yuto Kataoka, Yasufumi Tomioka, Morio Ueno, Koji Kitazawa, Hideki Fukuoka, Naoki Okumura, Noriko Koizumi, Chie Sotozono, Shigeru Kinoshita

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of ophthalmology case reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Yuto KataokaDepartment of Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan.
Yasufumi TomiokaDepartment of Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan.
Morio UenoDepartment of Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan.
Koji KitazawaDepartment of Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan.
Hideki FukuokaDepartment of Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan.
Naoki OkumuraDepartment of Biomedical Engineering, Faculty of Life and Medical Sciences, Doshisha University, Kyotanabe, Japan.
Noriko KoizumiDepartment of Biomedical Engineering, Faculty of Life and Medical Sciences, Doshisha University, Kyotanabe, Japan.
Chie SotozonoDepartment of Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan.
Shigeru KinoshitaDepartment of Frontier Medical Science and Technology for Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: To describe the 10-year clinical course after cultured human corneal endothelial cell (CEC) (cHCEC) transplantation combined with central descemetorhexis in a single patient with Fuchs endothelial corneal dystrophy (FECD). Observations: A 49-year-old Japanese male was referred to the Department of Ophthalmology at Kyoto Prefectural University of Medicine, Kyoto, Japan in 2013 due to decreased visual acuity (VA) and CEC loss in his left eye caused by FECD. Upon examination, FECD-related central corneal edema, cataract, and decreased VA were observed, and on September 4, 2014 the patient underwent cHCEC transplantation in his left eye. Intraoperatively, a Descemet membrane (DM) tear occurred while abnormal CECs were being removed, thus requiring a change in the surgical plan. Subsequently, the DM was completely stripped (descemetorhexis) in an approximately 5-mm-diameter area including the pupillary center, followed by cHCEC transplantation into the anterior chamber. Prior to surgery, best-corrected VA (BCVA) was 20/50 and central corneal thickness (CCT) was 637 μm, yet corneal transparency was restored and BCVA improved to 20/20 at 6-months postoperative. At 10-years postoperative, a reasonable CEC density (CECD) was found to have adhered to the descemetorhexis area, with maintained corneal transparency; i.e., CCT measured 548 μm, CECD in the central area was 938 cells/mm Conclusion and importance: While prospective studies are needed to generalize safety and efficacy, this FECD case treated with cHCEC transplantation combined with descemetorhexis showed no serious adverse events and sustained corneal clarity with stable CECD and CCT.

Indexed as

Cell therapyCultured human corneal endothelial cellsDescemetorhexisDescemet stripping onlyEndothelial regenerationFuchs endothelial corneal dystrophyLong-term outcomes

Identifiers

PMID41467042
PMCPMC12744237

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.