Evidence map›Paper›PMID 41467003›Full record

ReviewFundamental research2025

Innovating transcranial magnetic stimulation treatment for post-traumatic stress disorder: Zapping away the bad memory.

Ti-Fei Yuan, Ting Wang, Shuoshuo Li, Pengfei Wei, Liping Wang, Bingxing Pan, Ji Hu, Shengxi Wu, Yuan Shen, Zengqiang Yuan and 1 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Fundamental research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Physical biomedical science.Fundamental research · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Ti-Fei YuanShanghai Key Laboratory of Psychotic disorders, Brain Health Institute, National Center for Mental Disorders, Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine and School of Psychology, Shanghai 200030, China.
Ting WangBeijing Institute of Basic Medical Sciences, Beijing 100850, China.
Shuoshuo LiBeijing Institute of Basic Medical Sciences, Beijing 100850, China.
Pengfei WeiCAS Key Laboratory of Brain Connectome and Manipulation, Shenzhen-Hong Kong Institute of Brain Science, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China.
Liping WangCAS Key Laboratory of Brain Connectome and Manipulation, Shenzhen-Hong Kong Institute of Brain Science, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China.
Bingxing PanSchool of Basic Medical Sciences, Jiangxi Medical College, Nanchang University, Nanchang 330031, China.
Ji HuSchool of Life Science and Technology, Shanghai Tech University, Shanghai 201210, China.
Shengxi WuDepartment of Neurobiology, School of Basic Medicine, Fourth Military Medical University, Xi'an 710032, China.
Yuan ShenAnesthesia and Brain Research Institute, Tongji University School of Medicine, Shanghai 200072, China.
Zengqiang YuanBeijing Institute of Basic Medical Sciences, Beijing 100850, China.
Haitao WuCo-Innovation Center of Neuroregeneration, Nantong University, Nantong 226019, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Post-traumatic stress disorder (PTSD) is a debilitating psychiatric condition characterized by dysregulated fear memory, emotional disturbances, and impaired cognition, driven by dysfunctions across multiple neural circuits and neuroinflammatory processes. While current treatments demonstrate limited efficacy, repetitive transcranial magnetic stimulation (rTMS) has emerged as a promising non-invasive intervention. This review synthesizes preclinical and clinical evidence, highlighting rTMS mechanisms-including enhanced neuroplasticity, normalizing network connectivity, and reducing neuroinflammation. We then propose five innovative strategies, including accelerated protocols, precision targeting using neuroimaging, neuroinformatic approaches, closed-loop systems, and biomarker-guided treatment. By bridging circuit-level insights with clinical innovation, rTMS offers a transformative approach to PTSD treatment, though standardization and personalized paradigms require further development and validation. Future research should integrate multimodal biomarkers with hybrid therapies to optimize outcomes.

Indexed as

Closed-loopNeuroinflammationNeuroplasticityPost-traumatic stress disorderRepetitive transcranial magnetic stimulation

Identifiers

PMID41467003
PMCPMC12744610

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.