ArticleCureus2025
Linagliptin-Induced Bullous Pemphigoid: A Case Report and Comprehensive Literature Review.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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0 citing papers in PubMed.
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bullous pemphigoid (BP) is an autoimmune blistering disorder predominantly affecting the elderly, presenting significant management challenges, especially in patients with multimorbidity and polypharmacy. This report details a complex case of a 94-year-old woman with new-onset BP following dipeptidyl peptidase-4 (DPP-4) inhibitor (linagliptin) initiation, complicated by diabetes mellitus, chronic kidney disease, hypertension, and dementia. We describe her clinical course, therapeutic challenges, and response to systemic corticosteroids combined with topical therapies. Furthermore, we comprehensively review the current evidence for emerging biological and targeted therapies (e.g., rituximab, dupilumab, omalizumab, and intravenous immunoglobulin) in BP management, highlighting their potential role in reducing corticosteroid dependence and improving outcomes in frail, comorbid patients. This case underscores the importance of the prompt recognition of drug-induced BP, individualized treatment plans considering comorbidities, and the growing promise of novel therapeutic strategies.
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