ArticleCureus2025
Bevacizumab-Associated Bowel Perforation Causing Evisceration.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bevacizumab is a monoclonal antibody that targets vascular endothelial growth factor (VEGF) and inhibits angiogenesis in solid organ tumors. Its use in conjunction with fluorouracil-based chemotherapy for the management of metastatic colorectal cancer (CRC) has proven effective. There is a known, rare chance of gastrointestinal perforation associated with its use. We present a case of a man in his 70s on bevacizumab for metastatic rectal cancer, who presented to the hospital with small bowel evisceration through perforation at his colostomy site, ostensibly caused by a chronic parastomal hernia and bevacizumab chemotherapy. He required emergent surgery. After undergoing resection of an ischemic segment of small bowel, the perforated segment of his colon, and primary repair of his parastomal hernia, and fashioning of a new end colostomy, he recovered well and left the hospital two weeks later. After discharge from the hospital, he was able to continue with palliative chemotherapy.
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Registered trials
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