ArticleCureus2025
Extreme Rapid Eye Movement Rebound Exceeding Three Hours During Continuous Positive Airway Pressure Titration Despite High-Dose Antidepressant Therapy: A Case Report.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
5 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Rapid eye movement (REM) rebound following the initiation of continuous positive airway pressure (CPAP) is commonly observed, with episodes exceeding two hours being rare. We report a 38-year-old male with severe obstructive sleep apnea (OSA) (apnea-hypopnea index (AHI) = 74.2/hour) receiving fluoxetine 80 mg daily and trazodone 100 mg, who had a 206.5-minute continuous REM sleep episode during CPAP titration, followed by 66.5 minutes of stage N3 sleep. This duration exceeds previously reported continuous REM episodes during titration. This case demonstrates that severe OSA-related sleep fragmentation can overcome potent pharmacological REM suppression when effective treatment is initiated.
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