Radiographic and histomorphometric evaluation of Autogenous Particulated Dentin for Alveolar Ridge Preservation: A Systematic Review and Meta-analyses.

Background: The present systematic review aimed to identify and summarize the radiographic and histological outcomes of alveolar ridge preservation (ARP) using autogenous particulate dentin (APD) compared with spontaneous healing (SH) or other materials in alveolus post-extraction. Material and Methods: The protocol of this PRISMA systematic review was registered in PROSPERO (CRD42021245740). Clinical trials (CT) fulfilling specific eligibility criteria were included. Screening, data extraction and quality assessment were conducted by two reviewers. Study results were summarized using random effect metanalyses to synthesize the findings of the trials. Results: Fourteen articles concerning ten Randomized CT were included, involving a total of 304 participants, reporting data from 458 sockets. Most of the studies were considered as "unclear" risk of bias. Metanalyses indicated less horizontal at coronal third (difference in weighted means (WMD) = 2.04 mm; p<0.001) and middle third (WMD = 1.52 mm; p=0.002) bone resorption in ARP with APD compared to spontaneous healing assessed radiographically. However, no statistical significance was reached in the apical third (WMD = 0.33 mm; p=0.435) or in the vertical dimensional changes (at buccal aspect, WMD = 0.19 mm; p=0.789; and at lingual aspect, WMD = 0.44 mm; p=0.271). It was not possible to perform a meta-analysis for histomorphometric. Conclusions: ARP with APD is an effective therapy to attenuate post-extraction bone resorption and ridge changes, especially in the coronal width of the socket.