Evidence map›Paper›PMID 41466819›Full record

ArticleNeurobiology of pain (Cambridge, Mass.)

FL/FLT3 signaling enhances mechanical pain hypersensitivity through Interleukin-1 beta (IL-1β) in male mice.

Corinne Sonrier, Chamroen Sar, Ivo Melo, Lucie Dioufoulet, Gabriel V Lucena-Silva, Sylvie Mallié, Juliette Bertin, Jean-Philippe Leyris, Fabrice Ango, Thiago M Cunha and 4 more

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Article in Neurobiology of pain (Cambridge, Mass.). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Corinne SonrierUniversité de Montpellier, Montpellier, France.
Chamroen SarUniversité de Montpellier, Montpellier, France.
Ivo MeloCenter for Research in Inflammatory Diseases (CRID), Department of Pharmacology, Ribeirão Preto Medical School, University of Sao Paulo (USP), Ribeirão Preto, Brazil.
Lucie DioufouletUniversité de Montpellier, Montpellier, France.
Gabriel V Lucena-SilvaCenter for Research in Inflammatory Diseases (CRID), Department of Pharmacology, Ribeirão Preto Medical School, University of Sao Paulo (USP), Ribeirão Preto, Brazil.
Sylvie MalliéUniversité de Montpellier, Montpellier, France.
Juliette BertinUniversité de Montpellier, Montpellier, France.
Jean-Philippe LeyrisUniversité de Montpellier, Montpellier, France.
Fabrice AngoUniversité de Montpellier, Montpellier, France.
Thiago M CunhaCenter for Research in Inflammatory Diseases (CRID), Department of Pharmacology, Ribeirão Preto Medical School, University of Sao Paulo (USP), Ribeirão Preto, Brazil.
Hamid Moha Ou MaatiUniversité de Montpellier, Montpellier, France.
Jean ValmierUniversité de Montpellier, Montpellier, France.
Cyril RivatUniversité de Montpellier, Montpellier, France.
Ilana MéchalyUniversité de Montpellier, Montpellier, France.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Fms-like tyrosine kinase 3 (FLT3) plays a critical role in chronic pain through its ligand FL, a cytokine that triggers mechanical pain hypersensitivity. However, the underlying molecular mechanisms remain unclear. Here, we investigate the potential interplay between FL and IL-1β a key cytokine in DRG neurons sensitization and mechanical hyperalgesia through both

Indexed as

CytokineNeuroinflammationPainSensory neuronsTyrosine kinase receptor

Identifiers

PMID41466819
PMCPMC12744640

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.