ArticleJTCVS open2025
Right ventricular adaptation in congenital heart disease: Does the type of right ventricular overload matter?
Article in JTCVS open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Long-Term Effects of Right Ventricular Pressure and Volume Overload: A Comparative Analysis in an Ovine Model.Journal of clinical medicine · 2026Article
Corrections and comments
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Right ventricular (RV) function is an independent predictor of prognosis in congenital heart disease (CHD), but RV adaptation to chronic pressure and/or volume overload is understudied. This study aimed to assess adaptation to chronic RV pressure and/or volume overload in CHD patients using pressure-volume (PV) loop analysis. Methods: This retrospective study included CHD patients with a subpulmonary morphologic right ventricle and biventricular circulation who underwent right heart catheterization (RHC) and cardiac magnetic resonance (CMR) imaging within 12 months prior to RHC at the University Medical Center Utrecht between August 2013 and November 2024. RV volumes, function, pressures and wall tension were obtained. RV afterload (arterial elastance [Ea]), contractility (end-systolic elastance [Ees]), RV-pulmonary artery (PA) coupling (Ees/Ea), and diastolic stiffness (end-diastolic elastance [Eed]) were evaluated using PV loop analysis. Results: Forty-five patients (67% male; median age, 14 [interquartile range, 9-17] years; 18 with pressure overload, 7 with volume overload, 20 with combined overload) were included. Pressure and combined overload led to a twofold increase in Ea, increased Ees, and increased Eed compared to volume overload (all Conclusions: Despite similar RV function on conventional imaging, PV analysis revealed distinct RV adaptation patterns for RV pressure and/or volume overload in CHD, suggesting potential for RV overload-specific treatments.
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