Evidence map›Paper›PMID 41466790›Full record

ArticleJTCVS open2025

Resectable non-small cell lung cancer in women: A disease-specific entity?

Marisa Sewell, Thomas Boerner, Nicolas Toumbacaris, Kay See Tan, Giye Choe, Caitlin Harrington, Smita Sihag, Prasad S Adusumilli, Matthew J Bott, Robert J Downey and 8 more

Abstract read
In one paragraph

Article in JTCVS open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Marisa SewellThoracic Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY.
Thomas BoernerThoracic Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY.
Nicolas ToumbacarisDepartment of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY.
Kay See TanDepartment of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY.
Giye ChoeThoracic Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY.
Caitlin HarringtonThoracic Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY.
Smita SihagThoracic Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY.
Prasad S AdusumilliThoracic Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY.
Matthew J BottThoracic Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY.
Robert J DowneyThoracic Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY.
James HuangThoracic Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY.
James M IsbellThoracic Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY.
Bernard J ParkThoracic Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY.
Gaetano RoccoThoracic Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY.
Katherine GrayThoracic Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY.
Valerie W RuschThoracic Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY.
David R JonesThoracic Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY.
Daniela MolenaThoracic Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY.

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI SELWYN M VICKERS · 1985 to 2026
$347.4M
NCI NIH HHS P30 CA008748
6 · The paper itself

Abstract

Objective: There may be important sex-specific differences among patients with non-small cell lung cancer (NSCLC). Despite this, women are underrepresented in prospective clinical trials. We evaluated sex-specific differences in clinicopathologic and genetic factors and survival among patients with NSCLC. Methods: This is a single-center study at a high-volume dedicated cancer hospital. Patients with NSCLC who underwent complete surgical resection from 2010 to 2018 were included. Primary outcomes include cumulative incidence of recurrence and overall survival, stratified by sex. Results: Overall, 3452 patients were included; 2033 (59%) were women. More women than men were never-smokers (24% vs 13%; Conclusions: Clinicopathologic and genetic factors and survival among patients with NSCLC differ on the basis of sex. NSCLC in women should be considered a disease-specific entity.

Indexed as

EGFRKRASlung cancer in womennon−small cell lung cancer

Identifiers

PMID41466790
PMCPMC12745005

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.