ArticleJournal of surgical case reports2026
Gallbladder adenosquamous carcinoma: a case report and a review of the role of laparoscopy in managing a rare entity.
Article in Journal of surgical case reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Gallbladder adenosquamous carcinoma is a rare, aggressive malignancy (1%-10% of gallbladder cancers), with National Comprehensive Cancer Network guidelines not differentiating between histological subtypes. Radical cholecystectomy remains the only curative treatment, though laparoscopic feasibility is debated. We present a woman in her 50s with abdominal discomfort and imaging showing gallbladder wall thickening and an "hourglass appearance". Diagnostic laparoscopy revealed a firm mass without metastasis. Following laparoscopic cholecystectomy, intraoperative pathology confirmed adenocarcinoma, prompting immediate radical cholecystectomy, initiated laparoscopically, completed via open approach. Pathology demonstrated a 2.7 cm moderately differentiated adenosquamous carcinoma with negative margins and uninvolved lymph nodes (pT2aN0). Adjuvant chemotherapy was administered, and the patient was disease-free at one year follow-up. Documenting such rare cases is essential for advancing disease understanding. This case underscores the potential for favourable prognosis with early detection and highlights the value of integrating laparoscopic techniques in a multidisciplinary approach to optimize surgical outcomes while balancing safety and recovery.
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