ArticleHealth science reports2025
Prognostic Role of Inflammatory Biomarkers in Gastrointestinal Neuroendocrine Neoplasms: A Cross-Sectional Study.
Article in Health science reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Systemic Inflammation and Survival in Stage IV Colorectal Cancer: A Retrospective Cohort Study.Journal of clinical medicine · 2026Article
- Prognostic Role of Inflammatory Biomarkers in Gastrointestinal Neuroendocrine Neoplasms: A Cross-Sectional Study.Health science reports · 2025Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background and Aims: Gastrointestinal neuroendocrine neoplasms (g-NENs) represent a heterogeneous group of tumors with variable prognoses. Inflammation-based markers, such as the neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR), have emerged as potential prognostic indicators in various malignancies. This study aimed to evaluate the prognostic significance of NLR and PLR in g-NENs and their associations with histopathological features and survival outcomes. Methods: A retrospective, cross-sectional study was conducted on 80 patients with histologically confirmed g-NENs from April 2017 to March 2019. Baseline NLR and PLR were calculated, and their relationships with tumor grade, Ki-67 proliferation index, metastatic status, and survival outcomes were analyzed. Cox regression and logistic regression models were used to determine independent prognostic factors. Results: The hazard of death was approximately one-third in the low NLR group after adjusting for metastasis and tumor grade (HR = 0.33, 95% CI: 0.14-0.80, Conclusion: Our findings suggest that NLR may serve as an independent and accessible prognostic marker in g-NENs, potentially offering a cost-effective tool to support clinical decision-making. The combined assessment of inflammatory biomarkers and histopathological parameters could improve prognostic accuracy and help guide personalized management strategies in patients with g-NENs. Nevertheless, these observations should be interpreted with caution due to the retrospective, single-center design and limited sample size. Future large-scale, prospective studies are warranted to confirm and expand upon these results.
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