Evidence map›Paper›PMID 41466705›Full record

ArticleBioinformation2025

Impact of aloe vera on post-surgical wound healing in chronic periodontitis patients undergoing periodontal flap surgery: A randomized controlled trial.

Manvi Chandra Agrawal, Indrani Bharadwaj, Prerna Agarwal, Ashutosh Agarwal, Geetika Kumar, Somya Tiwari

Abstract read
In one paragraph

Article in Bioinformation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Comparative Evaluation of Locally DeliveredInternational journal of dentistry · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Manvi Chandra AgrawalDepartment of Periodontology and Implantology, Institute of dental sciences Bareilly, Uttar Pradesh, India.
Indrani BharadwajDepartment of Periodontology and Implantology, Institute of dental sciences Bareilly, Uttar Pradesh, India.
Prerna AgarwalDepartment of Periodontology and Implantology, Institute of dental sciences Bareilly, Uttar Pradesh, India.
Ashutosh AgarwalDepartment of Periodontology and Implantology, Institute of dental sciences Bareilly, Uttar Pradesh, India.
Geetika KumarDepartment of Periodontology and Implantology, Institute of dental sciences Bareilly, Uttar Pradesh, India.
Somya TiwariDepartment of Periodontology and Implantology, Institute of dental sciences Bareilly, Uttar Pradesh, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Periodontal flap surgery is widely performed for pocket reduction, but healing may be delayed by inflammation. Among the recent emergence of herbal and ayurvedic plants, Aloe vera is one such succulent plant which has been used for its anti-inflammatory, anti-microbial properties and it also may enhance surgical outcomes. Therefore, it is of interest to assess the effect of topical aloe vera gel on postoperative healing, probing pocket depth and clinical attachment loss following periodontal flap surgery. Hence, thirty patients with Stage II/III periodontitis were randomly assigned into test (aloe vera gel) and control (Co-E pack) groups. Flap surgeries were conducted on the patients. Postoperative healing was assessed using the Early Healing Index (EHI) at one week and the Healing Index (HI) at one, two and three weeks. PPD and CAL were recorded pre- and postoperatively. The aloe vera group showed significantly higher EHI scores at one week and higher HI scores at week two and three. Both groups improved over time, but PPD reduction and CAL gain were greater with aloe vera. Superior healing was seen in the aloe vera group regardless of disease severity. Thus, topical aloe vera gel significantly improved postoperative healing, PPD and CAL following flap surgery, suggesting its potential as a safe, effective adjunct in periodontal therapy.

Indexed as

Aloe veraflap surgeryperiodontitiswound healing

Identifiers

PMID41466705
PMCPMC12744424

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.