ArticleBioinformation2025
Direct versus conventional sonication for the diagnosis of joint infection: A comparative study.
Article in Bioinformation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
7 authors.
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Abstract
Periprosthetic joint infection (PJI) remains a major cause of revision arthroplasty, and accurate diagnostic methods are essential. In this comparative study of 196 revision cases (94 direct vs. 102 conventional sonication), 116 (59.2%) met criteria for PJI. Direct sonication achieved higher sensitivity (86.2%, 95% CI 78.3-92.0) compared with conventional sonication (70.7%, 95% CI 60.4-79.5; p < 0.01), while specificity was comparable (90.3% vs. 94.4%). Importantly, the time-to-positivity (TTP) was significantly shorter with direct sonication (median 2.1 days vs. 3.0 days; p = 0.002), particularly for Gram-positive organisms. These findings demonstrate that direct sonication enhances diagnostic yield, accelerates pathogen recovery, and supports its integration into standardized PJI diagnostic pathways for earlier targeted therapy.
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