Evidence map›Paper›PMID 41466314›Full record

ArticleEuropean journal of medical research2025

High glucose induces osteoblasts ferroptosis via the TXNIP/Trx-1/GPX4 pathway in type 2 diabetic osteoporosis.

Yantao Zhao, Di Xiao, Miao Zeng, Yijie Gao, Anquan Huang, Changle Ren, Yunxia Du

Abstract read
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In one paragraph

Article in European journal of medical research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Yantao Zhao *Department of Joint Surgery, Central Hospital of Dalian University of Technology, Dalian, China.
Di Xiao *Department of Joint Surgery, Central Hospital of Dalian University of Technology, Dalian, China.
Miao ZengDepartment of Rehabilitation Medicine, The Second Hospital of Dalian Medical University, Dalian, China.
Yijie GaoDepartment of Joint Surgery and Sports Medicine, Institute of Science Tokyo, Tokyo, Japan.
Anquan HuangDepartment of Joint Surgery, Central Hospital of Dalian University of Technology, Dalian, China.
Changle RenDepartment of Joint Surgery, Central Hospital of Dalian University of Technology, Dalian, China.
Yunxia DuDepartment of Rehabilitation Medicine, The Second Hospital of Dalian Medical University, Dalian, China. dyx90116@163.com.

Funding

Dalian Medical Science Research Program Project 2211004
6 · The paper itself

Abstract

Type 2 diabetic osteoporosis (T2DOP) is characterized by impaired bone formation and increased fracture susceptibility; however, the molecular mechanisms linking hyperglycemia to osteoblast dysfunction remain insufficiently defined. In this study, we demonstrate that high glucose (HG) triggers ferroptosis in osteoblasts through activation of the thioredoxin-interacting protein (TXNIP)/thioredoxin-1 (Trx-1)/glutathione peroxidase 4 (GPX4) pathway, leading to reduced cell viability, bioenergetic failure, and impaired osteogenic differentiation. HG exposure induced hallmark ferroptotic features-including excessive intracellular ferrous iron (Fe

Indexed as

Carrier ProteinsDiabetes Mellitus, Type 2FerroptosisGlucoseOsteoblastsOsteoporosisPhospholipid Hydroperoxide Glutathione PeroxidaseThioredoxinsAnimalsCell Cycle ProteinsHumansMaleMiceRatsReactive Oxygen SpeciesSignal TransductionCarrier ProteinsCell Cycle ProteinsGlucoseglutathione peroxidase 4, ratPhospholipid Hydroperoxide Glutathione PeroxidaseReactive Oxygen SpeciesThioredoxinsTxn1 protein, ratTXNIP protein, ratFerroptosisGlutathione peroxidase 4Thioredoxin-1Thioredoxin-interacting proteinType 2 diabetic osteoporosis

Identifiers

PMID41466314
PMCPMC12859983

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.