ArticleAlzheimer's research & therapy2025
Thirty-seven-year trends in the prevalence, incidence, and prognosis of dementia in a Japanese community: the Hisayama study.
Article in Alzheimer's research & therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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5 citing papers in PubMed.
- Contact experience with people living with dementia and dementia-related stigma domains among old-old adults: A cross-sectional study.PCN reports : psychiatry and clinical neurosciences · 2026Article
- The growing burden of dementia in Asia: Comparative insights from Japan, China, and India.The journal of prevention of Alzheimer's disease · 2026Article
- Review
- Epidemiological and clinical evidence on blood pressure management for the prevention of dementia: striving for a healthy 100-year life.Hypertension research : official journal of the Japanese Society of Hypertension · 2026Review
- Cognitive and behavioral benefits of newspaper reading in community-dwelling older adults: a feasibility randomized controlled trial.Frontiers in aging · 2026Article
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Abstract
backgroundFew population-based studies have investigated how the prevalence, incidence, and survival rate of dementia have changed since the 2010s in Asian communities. We investigated this issue using 37 years of epidemiological data in a Japanese community.
methodsSeven cross-sectional surveys of dementia were conducted among residents aged ≥ 65 years in a Japanese community in 1985, 1992, 1998, 2005, 2012, 2017, and 2022. We also established three cohorts in the residents aged ≥ 65 years without dementia in 1988 (n = 803), 2002 (n = 1,231), and 2012 (n = 1,519), each of which was followed for 10 years. Trends in the prevalence of dementia were tested using a logistic regression model. The age- and sex-adjusted incidence of dementia and survival rate after dementia onset were compared across cohorts using a Cox proportional hazards model.
resultsThe crude prevalence of dementia significantly increased from 1985 to 2012 (6.7% in 1985, 5.7% in 1992, 7.1% in 1998, 12.5% in 2005, and 17.9% in 2012, p for trend < 0.01), but then decreased significantly from 2012 to 2022 (15.8% in 2017 and 12.1% in 2022; p for trend < 0.01). A similar trend was observed after adjusting for age and sex. Moreover, the age- and sex-adjusted incidence of dementia increased significantly from the 1988 to the 2002 cohort (adjusted hazard ratio [aHR] 1.68, 95% confidence intervals [CI] = 1.38-2.06), but decreased significantly from the 2002 to the 2012 cohort (aHR = 0.60, 95% CI = 0.51-0.70). The age- and sex-adjusted 5-year survival rate after dementia onset increased significantly from the 1988 to the 2002 cohort (47.3% to 65.2%; p < 0.01), while no significant change was observed from the 2002 to the 2012 cohort (65.2% to 58.9%; p = 0.42).
conclusionsDecreasing trends in the prevalence and incidence of dementia were observed since 2012 in a Japanese community. The decline in the incidence of dementia may be due to the prevention and improved management of lifestyle-related diseases, such as hypertension and diabetes, as well as increased awareness and promotion of healthy lifestyle behaviors.
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