ArticleBMC complementary medicine and therapies2025
Combined effects of honey and silver nanoparticles on wound healing in human dermal fibroblast cells.
Article in BMC complementary medicine and therapies, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Multifunctional Hydrogel with Phytochemicals and Silver Nanoparticles for Promoting Scar-Free Wound Healing.Gels (Basel, Switzerland) · 2026Article
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Authors and funding
5 authors.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundWound healing is a complex process requiring coordinated cellular responses. Honey and silver nanoparticles (AgNPs) are well-known for their potential to heal wounds. However, there is little evidence of their combined impact on wound healing in fibroblast cells. This study aimed to investigate the combined effects of two types of honey with AgNPs on bacterial growth inhibition and wound healing in human dermal fibroblast cells.
methodHoney samples were characterized based on phenolic content, antioxidant capacity, and protein levels. The AgNPs were synthesized and characterized by dynamic light scattering, ultraviolet-visible, transmission electron microscopy, and X-ray powder diffraction. Antibacterial activity was assessed by checkerboard assay. The effect of honey, AgNPs, and their combination on fibroblast cell viability and wound healing was evaluated. Quantitative real-time PCR was conducted to evaluate the mRNA expression of growth factors.
resultsOur results showed that Barberry honey significantly increased fibroblast cell growth, wound healing, and expression of FGF2, TGFβ1, COL1A1, and VEGFA genes compared to commercial honey. Combination of honey with AgNPs significantly increased VEGFA gene expression compared to either agent alone. Barberry honey and AgNPs also showed strong antibacterial effects individually. However, their combination had no synergistic effect.
conclusionThese findings suggest that Barberry honey and its combination with AgNPs could serve as effective agents for promoting the fibroblast wound healing process. However, more in vitro and in vivo research is needed to investigate further mechanisms of Barberry honey alone and in combination with AgNPs in wound healing.
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