Evidence map›Paper›PMID 41466154›Full record

ArticleHeart and vessels2026

Predictive ability of microvascular resistance reserve for periprocedural myocardial injury in patients with stable coronary artery disease undergoing percutaneous coronary intervention.

Mikio Shigehara, Hiroki Ikenaga, Yuki Yoshitomi, Hiroshi Kobatake, Atsushi Kuraishi, Ayano Osawa, Takayuki Nakano, Yuichi Morita, Tasuku Higashihara, Noriaki Watanabe and 2 more

Abstract read
In one paragraph

Article in Heart and vessels, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Mikio ShigeharaDepartment of Cardiovascular Medicine, Hiroshima University Graduate School of Biomedical and Health Sciences, 1-2-3 Kasumi, Minami-ku, Hiroshima, 734-8551, Japan.
Hiroki IkenagaDepartment of Cardiovascular Medicine, Hiroshima University Graduate School of Biomedical and Health Sciences, 1-2-3 Kasumi, Minami-ku, Hiroshima, 734-8551, Japan. hirokiikenaga@yahoo.co.jp.ORCID http://orcid.org/0000-0001-7614-2783
Yuki YoshitomiDepartment of Cardiovascular Medicine, Hiroshima University Graduate School of Biomedical and Health Sciences, 1-2-3 Kasumi, Minami-ku, Hiroshima, 734-8551, Japan.
Hiroshi KobatakeDepartment of Cardiovascular Medicine, Hiroshima University Graduate School of Biomedical and Health Sciences, 1-2-3 Kasumi, Minami-ku, Hiroshima, 734-8551, Japan.
Atsushi KuraishiDepartment of Cardiovascular Medicine, Hiroshima University Graduate School of Biomedical and Health Sciences, 1-2-3 Kasumi, Minami-ku, Hiroshima, 734-8551, Japan.
Ayano OsawaDepartment of Cardiovascular Medicine, Hiroshima University Graduate School of Biomedical and Health Sciences, 1-2-3 Kasumi, Minami-ku, Hiroshima, 734-8551, Japan.
Takayuki NakanoDepartment of Cardiovascular Medicine, Hiroshima University Graduate School of Biomedical and Health Sciences, 1-2-3 Kasumi, Minami-ku, Hiroshima, 734-8551, Japan.
Yuichi MoritaDepartment of Cardiovascular Medicine, Hiroshima University Graduate School of Biomedical and Health Sciences, 1-2-3 Kasumi, Minami-ku, Hiroshima, 734-8551, Japan.
Tasuku HigashiharaDepartment of Cardiovascular Medicine, Hiroshima University Graduate School of Biomedical and Health Sciences, 1-2-3 Kasumi, Minami-ku, Hiroshima, 734-8551, Japan.
Noriaki WatanabeDepartment of Cardiovascular Medicine, Hiroshima University Graduate School of Biomedical and Health Sciences, 1-2-3 Kasumi, Minami-ku, Hiroshima, 734-8551, Japan.
Yoshiharu SadaDepartment of Cardiovascular Medicine, Hiroshima University Graduate School of Biomedical and Health Sciences, 1-2-3 Kasumi, Minami-ku, Hiroshima, 734-8551, Japan.
Yukiko NakanoDepartment of Cardiovascular Medicine, Hiroshima University Graduate School of Biomedical and Health Sciences, 1-2-3 Kasumi, Minami-ku, Hiroshima, 734-8551, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Periprocedural myocardial injury (PMI) has shown an association with worse prognosis after percutaneous coronary intervention (PCI). The microvascular resistance reserve (MRR) has been introduced as an index to evaluate microvascular vasodilatory capacity, independent of epicardial disease. Given the unclear association between MRR and PMI, this study aimed to determine the relationship between PMI and coronary microvascular dysfunction, including index of microcirculatory resistance (IMR) and MRR. This study identified 68 patients with stable angina pectoris who underwent PCI after measurements of coronary circulatory physiological indices at Hiroshima University Hospital between October 2017 and October 2024. PMI was assessed by a post-PCI high-sensitivity troponin T level > 5 times the 99th percentile of the normal upper limit (> 0.07 ng/mL). In total, 57 patients were enrolled, of which 18 (31.6%) had elevation of troponin T > 0.07 ng/mL after PCI and were classified into the PMI group. Significantly worse measurements of IMR (33.7 [24.0–43.8] vs. 26.0 [15.9–33.0], p = 0.029) and MRR (2.95 [2.28–4.00] vs. 4.29 [3.01–5.74], p = 0.009) were documented in the PMI group. After multivariable logistic regression analyses, both MRR (OR 0.464; 95% CI 0.234–0.919; p = 0.028) and IMR (OR 1.060; 95% CI 1.000–1.1830; p = 0.041) were identified as predictive factors of PMI. Both MRR and IMR before PCI were independent predictors of PMI.

Indexed as

Coronary Artery DiseaseCoronary CirculationCoronary VesselsMicrocirculationPercutaneous Coronary InterventionVascular ResistanceAgedCoronary AngiographyFemaleHumansMaleMiddle AgedPredictive Value of TestsPrognosisRetrospective StudiesRisk FactorsTroponin TCoronary microvascular dysfunctionIndex of microcirculatory resistanceMicrovascular resistance reservePercutaneous coronary interventionPeriprocedural myocardial injury

Identifiers

PMID41466154
PMCPMC13272597

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.