Evidence map›Paper›PMID 41466145›Full record

ArticleNature cell biology2026

T follicular helper cells transiently unlock a plasticity state in germinal centre B cells during the humoral immune response.

Laurianne Scourzic, Franco Izzo, Matt Teater, Alexander P Polyzos, Lucretia Cucereavii, Christopher R Chin, Antonin Papin, Hugo B Pinto, Coraline Mlynarczyk, Ioanna Tsialta and 14 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature cell biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Neuro-tumor interactions in peripheral tumors.Cancer metastasis reviews · 2026
    Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors.

Laurianne ScourzicSanford I. Weill Department of Medicine, Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA. lls2002@med.cornell.edu.ORCID http://orcid.org/0000-0003-2875-1642
Franco Izzo *Sanford I. Weill Department of Medicine, Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA.ORCID http://orcid.org/0000-0002-5813-6504
Matt Teater *Sanford I. Weill Department of Medicine, Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA.
Alexander P Polyzos *Sanford I. Weill Department of Medicine, Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA.ORCID http://orcid.org/0000-0002-2509-9698
Lucretia CucereaviiSanford I. Weill Department of Medicine, Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA.
Christopher R ChinSanford I. Weill Department of Medicine, Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA.ORCID http://orcid.org/0000-0002-2140-3197
Antonin PapinDepartment of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, USA.
Hugo B PintoDepartment of Cell Biology, Albert Einstein College of Medicine, New York, NY, USA.
Coraline MlynarczykSanford I. Weill Department of Medicine, Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA.ORCID http://orcid.org/0000-0002-6750-0240
Ioanna TsialtaSanford I. Weill Department of Medicine, Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA.ORCID http://orcid.org/0009-0004-5666-775X
Min XiaSanford I. Weill Department of Medicine, Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA.ORCID http://orcid.org/0000-0002-1093-5008
Abigail LidoskiSanford I. Weill Department of Medicine, Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA.ORCID http://orcid.org/0009-0006-5348-4135
Robert M MyersSanford I. Weill Department of Medicine, Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA.
Eva M IsraelStrathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, UK.ORCID http://orcid.org/0000-0001-9533-2881
Leandro VenturuttiCentre for Lymphoid Cancer and Terry Fox Laboratory, BC Cancer, Vancouver, British Columbia, Canada.
Simon P MackayStrathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, UK.
Kenneth B HoehnDepartment of Biomedical Data Science and Dartmouth Cancer Center, Geisel School of Medicine at Dartmouth, Hanover, NH, USA.
Arthur I SkoultchiDepartment of Cell Biology, Albert Einstein College of Medicine, New York, NY, USA.
Wendy BéguelinSanford I. Weill Department of Medicine, Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA.ORCID http://orcid.org/0000-0002-4894-9229
Matthias StadtfeldSanford I. Weill Department of Medicine, Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA.ORCID http://orcid.org/0000-0002-5852-9906
Zhengming ChenDivision of Biostatistics, Department of Population Health Sciences, Weill Cornell Medicine, New York, NY, USA.
Dan A LandauSanford I. Weill Department of Medicine, Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA.
Ari M MelnickSanford I. Weill Department of Medicine, Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA. amm2014@med.cornell.edu.ORCID http://orcid.org/0000-0002-8074-2287
Effie ApostolouSanford I. Weill Department of Medicine, Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA. efa2001@med.cornell.edu.ORCID http://orcid.org/0000-0002-8111-0863

Funding

Translational Engineering in Cancer (TEC)P30CA023108 · NCI · DARTMOUTH COLLEGE · PI Fred W Kolling IV · 1985 to 2026
$91.3M
Functions of Mammalian H1 Linker Histones in Gene Regulation and Chromatin ActivityR01GM147165 · NIGMS · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI SKOULTCHI, ARTHUR I · 2022 to 2025
$2.1M
Characterizing stem cell-like B cell subpopulations and dissecting their role in tumorigenesisR01CA283327 · NCI · WEILL MEDICAL COLL OF CORNELL UNIV · PI Effie Apostolou · 2023 to 2026
$1.6M
NCI NIH HHS P30 CA023108NCI NIH HHS R01 CA283327NIGMS NIH HHS R01 GM147165U.S. Department of Health & Human Services | NIH | NCI | Division of Cancer Epidemiology and Genetics, National Cancer Institute (National Cancer Institute Division of Cancer Epidemiology and Genetics) 1R01CA283327
6 · The paper itself

Abstract

During the germinal centre (GC) reaction, mature B cells undergo rapid and reversible phenotypic shifts that are essential for adaptive immunity. Here we report that GC B cells, unlike other mature B cells, transiently acquire a unique epigenetic plasticity, demonstrated by their enhanced capacity to reprogram to induced pluripotent stem cells. This plasticity depends on T follicular helper (T

Indexed as

B-LymphocytesCell PlasticityGerminal CenterImmunity, HumoralT Follicular Helper CellsT-Lymphocytes, Helper-InducerAnimalsCell DifferentiationEpigenesis, GeneticHistonesHumansLymphoma, B-CellMiceMice, Inbred C57BLNF-kappa BSignal TransductionHistonesNF-kappa B

Identifiers

PMID41466145
PMCPMC13070251

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.