Evidence map›Paper›PMID 41466102›Full record

ArticleJournal of microbiology and biotechnology2025

Optimizing L-Tryptophan Production in

Tongxin Wan, Dongqin Ding, Junqing Chen, Yaru Zhu, Huiying Wang, Zixiang Xu, Junlin Yang, Yufeng Wang, Jia Song, Dawei Zhang

Abstract read
In one paragraph

Article in Journal of microbiology and biotechnology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Tongxin WanCollege of Biotechnology, Tianjin University of Science & Technology, Tianjin 300457, P.R. China.
Dongqin DingTianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin 300308, P.R. China.
Junqing ChenTianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin 300308, P.R. China.
Yaru ZhuTianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin 300308, P.R. China.
Huiying WangTianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin 300308, P.R. China.
Zixiang XuTianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin 300308, P.R. China.
Junlin YangYuxing Biotechnology (GROUP) CO., LTD., P.R. China.
Yufeng WangYuxing Biotechnology (GROUP) CO., LTD., P.R. China.
Jia SongCollege of Biotechnology, Tianjin University of Science & Technology, Tianjin 300457, P.R. China.
Dawei ZhangTianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin 300308, P.R. China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

L-tryptophan (L-trp) is a key aromatic amino acid with significant industrial value, and microbial fermentation provides a sustainable alternative to traditional chemical synthesis. However, low production yields due to inefficient microbial strains remain a major challenge. In this study, we enhanced L-trp production through redox engineering of

Indexed as

Escherichia coliMetabolic EngineeringMetabolomicsTryptophanChorismic AcidFermentationFructosephosphatesMetabolic Networks and PathwaysOxidation-ReductionPhosphoenolpyruvateShikimic AcidSugar PhosphatesChorismic Aciderythrose 4-phosphatefructose-6-phosphateFructosephosphatesPhosphoenolpyruvateShikimic AcidSugar PhosphatesTryptophanEscherichia colifermentation optimizationmetabolomics analysisredox engineering

Identifiers

PMID41466102
PMCPMC12790993

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.