Trial reportEuropean archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery2026
Intralesional steroid injection versus voice therapy for the management of early vocal fold nodules in female patients: a randomized controlled trial.
Trial report in European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
purposeWhile vocal fold steroid injection (VFSI) is emerging as a therapeutic approach for vocal fold nodules (VFNs), its comparative efficacy relative to standard voice therapy remains unestablished. This study aimed to evaluate and contrast treatment findings between VFSI and voice therapy for VFNs.
methodsIn a randomized controlled trial, 50 female patients with VFNs received either percutaneous intralesional triamcinolone injection or Accent method voice therapy. Serial evaluations-including videoendoscopic (nodule size, mucosal wave, glottic gap), subjective (auditory perceptual assessment, Voice Handicap Index), and objective (acoustic, aerodynamic) measures-were conducted at baseline and at 1 week and 1-, 2-, 3-, and 6-months post-treatment.
resultsBoth groups demonstrated significant reductions in nodule size and improvements in mucosal wave patterns and glottic gaps over the 6 months (p < 0.05). Most subjective and objective measures also enhanced significantly in both groups over the same study period (p < 0.05). However, voice therapy outperformed VFSI in most parameters (videoendoscopic, subjective, and objective) by the end of the third month (p < 0.05) and in nodule size reduction by the sixth month (p = 0.049).
conclusionsVFSI is a rapid and reliable therapeutic solution for VFNs with outcomes comparable to voice therapy. Long-term data, however, demonstrate voice therapy better prevents nodule recurrence. Therefore, subsequent voice therapy or repeated injections may enhance the long-term efficacy of VFSI.
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