ArticleJournal of cutaneous pathology2026
Acral Mesenchymal Spindle Cell Neoplasm With a Novel HMGA2::NCOA2 Fusion.
Article in Journal of cutaneous pathology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Molecular profiling has revolutionized the field of soft tissue pathology, enhancing diagnostic precision and treatment strategies. The integration of molecular analysis and immunohistochemistry has been crucial for classifying diagnostically challenging acral mesenchymal neoplasms. Herein, we report the first documented case of an acral mesenchymal spindle cell neoplasm harboring an HMGA2::NCOA2 fusion. The neoplasm presented as a slow-growing verrucous papule on the right thumb of an 18-year-old female. Histological examination revealed spindled cells of varying cellularity with intervening sclerotic collagen and dilated vasculature. The cells had patchy S100 and focal GLUT-1 reactivity but were negative for CD34, EMA, Sox-10, Pan-TRK, p63, CKAE1/3, MUC4, ALK, Factor 13A, actin, desmin, and ERG. Given the unusual morphology and non-diagnostic immunohistochemical profile, the specimen was sent for additional molecular profiling. Next-generation sequencing revealed a novel in-frame HMGA2::NCOA2 fusion. The tumor was likely benign, with 4 mitoses per 10 high-powered fields (HPF), but was excised due to the unpredictable behavior of the fusion. As the first known case to date with this fusion, these findings contribute to the emerging research on genomic testing in acral soft tissue tumors. Additional cases and longer clinical follow-up are needed to better characterize the novel HMGA2::NCOA2 fusion.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.