SynthesisMedicine2025
Efficacy and safety of traditional Chinese medicine injections for older adults with community-acquired pneumonia: An evidence map.
Synthesis in Medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
backgroundCommunity-acquired pneumonia (CAP) is a common respiratory condition associated with high morbidity and mortality. Older adults are disproportionately affected, experiencing higher risks and poorer outcomes. The current evidence regarding the efficacy and safety of traditional Chinese medicine injections (TCMIs) for CAP in older adults is limited. This study aims to synthesize high-quality evidence and identify gaps in the existing literature to guide future research.
methodsA systematic search was conducted in eight databases - PubMed, Cochrane Library, EMBASE, Web of Science, CNKI, VIP, Wanfang, and SinoMed - covering records from database inception to December 19, 2024. Randomized controlled trials (RCTs), systematic reviews, and meta-analyses (MAs) assessing the use of TCMIs for older adults with CAP were included. The risk of bias in RCTs was assessed using the Cochrane risk of bias tool. Evidence bubble plots were created to visualize the study characteristics and distribution of evidence.
resultsThe evidence map included 165 RCTs and one MAs, with the earliest publication dating from 2001. All studies were conducted in China, and RCTs accounted for 99% of the included evidence. Tanreqing Injection was the most frequently investigated intervention, with a median treatment duration of 7 to 13 days. The primary outcomes were the clinical effective rate and time to symptom resolution. Both the RCTs and the MAs reported significant benefits of TCMIs for older adults with CAP. However, the overall certainty of the evidence remains low.
conclusionTCMIs show substantial potential for improving clinical efficacy and alleviating symptoms in older adults with CAP. However, existing studies have design and methodological limitations. Future research should focus on improving methodological quality to enhance the robustness of the clinical evidence.
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