SynthesisMedicine2025
Iatrogenic atrial septal defect following transcatheter edge-to-edge mitral valve repair: A systematic review and meta-analysis.
Synthesis in Medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Acute deoxygenation during M-TEER: a note of caution.European heart journal. Imaging methods and practice · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTranscatheter edge-to-edge mitral valve repair (TEER) requires transseptal access of the left atrium, which usually causes an iatrogenic atrial septal defect (iASD). It is controversial that whether these patients with iASD persistence will progress to a bad prognostic state. So it's worthwhile to evaluate whether the procedure of TEER induced iASD leads to development of a relevant interatrial shunt. This systematic review and meta-analysis aimed to identify predictors of iASD persistence in patients with mitral regurgitation (MR) undergoing TEER and assess its effect on in-hospital outcomes and mortality.
methodsIn this systematic review and meta-analysis, we conducted a literature search in various databases. Our investigation summarized data from contemporary studies on the incidence of iASD following TEER for MR and its association with clinical outcomes.
results10 studies were analyzed, possible predictors of risk factors for the persistence of iASD after TEER seemed to be atrial fibrillation before surgery (OR 1.40; P = .04), residual MR > 2+(OR 2.36; P = .001), residual tricuspid regurgitation > mild(OR 1.52; P = .01), and prolonged fluoroscopic time(MD [in minutes] 5.36; P = .007). Patients with iASD persistence after TEER seemed to have a greater risk to suffer from right heart overload reflecting from the enlarged right ventricle end-diastolic dimension (RVEDD) (MD 3.27; P < .00001) and the enlarged diameter of the right atrium (MD 4.41; P < .00001). Patients with iASD persistence after TEER had a greater risk of heart failure rehospitalization (OR 2.71; P = .003).
conclusionThis systematic review and meta-analysis identified several related predictors of iASD persistence, possibly leading to right heart volume overload and a higher risk of heart failure rehospitalization. In order to generalize our findings, larger clinical studies in independent patient cohorts are necessary. What's more, there is a need to perform a careful decision for interventional closure of an iASD after TEER.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.