Evidence map›Paper›PMID 41465847›Full record

ArticleLife (Basel, Switzerland)2025

Molecular Drivers of Chromophobe Renal Cell Carcinoma Revealed Through Genomic Analysis Using AACR Project GENIE.

Abbi Gobel, Grace S Saglimbeni, Eugene Manu, Nikhita Tandon, Tyson J Morris, Akaash Surendra, Beau Hsia, Peter T Silberstein, Khalid Bashir, Abubakar Tauseef

Abstract read
In one paragraph

Article in Life (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Abbi GobelSchool of Life Sciences, Arizona State University, Tempe, AZ 85281, USA.
Grace S SaglimbeniSchool of Medicine, Creighton University, Phoenix, AZ 85012, USA.ORCID 0009-0006-1993-9554
Eugene ManuHofstra College of Liberal Arts and Sciences, Hempstead, NY 11549, USA.
Nikhita TandonSchool of Biological Sciences, University of California, Davis, CA 95616, USA.
Tyson J MorrisSchool of Medicine, Creighton University, Phoenix, AZ 85012, USA.ORCID 0009-0008-1457-591X
Akaash SurendraSchool of Life Sciences, Arizona State University, Tempe, AZ 85281, USA.ORCID 0009-0006-9693-4829
Beau HsiaSchool of Medicine, Creighton University, Phoenix, AZ 85012, USA.ORCID 0009-0009-6403-502X
Peter T SilbersteinSchool of Medicine, Creighton University, Omaha, NE 68178, USA.
Khalid BashirSchool of Medicine, Creighton University, Omaha, NE 68178, USA.
Abubakar TauseefSchool of Medicine, Creighton University, Omaha, NE 68178, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chromophobe renal cell carcinoma (chRCC) is a distinct subtype of non-clear cell renal cell carcinoma (ncRCC), arising from intercalated cells of the distal nephron collecting ducts. No standard treatments are specifically approved for chRCC, which is further hindered by lack of a universally accepted grading system. This study sought to find molecular drivers that may aid in the diagnosis or development of treatments for chRCC. A retrospective analysis of chRCC was conducted using data from the American Association for Cancer Research (AACR) Project Genomics Evidence Neoplasia Information Exchange (GENIE) repository, accessed through cBioPortal (version 17.0-public) on 21 July 2025. The study examined recurrent somatic mutations and assessed co-occurrence with Benjamini-Hochberg False Discovery Rate (FDR) correction. Additional analyses evaluated mutation by sex and race, with significance set at

Indexed as

chromophobe renal cell carcinomanon-clear renal cell carcinomarenal cell carcinoma

Identifiers

PMID41465847
PMCPMC12734498

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.