ArticleLife (Basel, Switzerland)2025
Ki-67 and Tumor Size in Small Bowel Tumors: Findings from an Exploratory Immunohistochemical Analysis.
Article in Life (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Surgical Complexity and Postoperative Outcomes in Recurrent Versus Primary Incisional Hernias Following Elective Retromuscular Repair: A Retrospective Cohort Study.Diagnostics (Basel, Switzerland) · 2026Article
- Impact of Disease Severity and Age on Outcomes After Laparoscopic Versus Open Appendectomy: A Single-Center Retrospective Cohort Study.Life (Basel, Switzerland) · 2026Article
- Gastrointestinal Health: Clinical Research and Therapeutic Innovations.Life (Basel, Switzerland) · 2026Article
- Article
- Immunohistochemical predictors of local recurrence in breast carcinoma: development and sensitivity validation of an IHC-based risk score.Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologieArticle
- Ileal neuroendocrine tumors: clinicopathological features and associations with systemic inflammatory and nutritional markers.Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologieArticle
- Primary cutaneous extraskeletal Ewing sarcoma of the plantar region: clinicopathological features and review of the literature.Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologieReview
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Authors and funding
8 authors.
Funding
Abstract
backgroundSmall bowel tumors are rare and biologically diverse, and prognostic assessment remains difficult, particularly regarding proliferative markers such as Ki-67 and tumor size.
objectiveTo evaluate the clinicopathological and immunohistochemical characteristics of small bowel tumors and explore factors associated with malignancy.
methodsA retrospective analysis of 61 surgically treated primary small bowel tumors (2020-2024) was performed using WHO 2019/2022 and AJCC 8th criteria. Immunohistochemistry included CD117, DOG1, CD34, SMA, and Ki-67.
resultsAdenocarcinomas were most frequent (52.5%), followed by GISTs (26.2%) and NETs (9.8%). CD117 and DOG1 were expressed in 93.8% of GISTs, confirming high diagnostic specificity. The median Ki-67 index was 8%, significantly higher in non-GIST tumors (
conclusionsTumor size and Ki-67 were associated with malignancy in this exploratory multivariable analysis, but these findings should be interpreted with caution due to limited follow-up and sample imbalance. Combined with CD117/DOG1 profiling, they enhance diagnostic accuracy and may inform diagnostic assessment; however, prognostic implications require outcome-based studies.
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