ArticleLife (Basel, Switzerland)2025
Uncovering New Antimelanoma Strategies: Experimental Insights into Semisynthetic Pentacyclic Triterpenoids.
Diana Ungureanu Similie, Larisa Bora, Sorin Dan Chiriac, Ștefana Avram, Daliana Minda, Jevgeņija Lugiņina, Vladislavs Kroškins, Māris Turks, Ioana Zinuca Magyari-Pavel, Ștefania Dinu and 2 more
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In one paragraphArticle in Life (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 · Who and what moneyAuthors and funding
12 authors.
Diana Ungureanu SimilieDepartment of Pharmacognosy-Phytotherapy, "Victor Babeș" University of Medicine and Pharmacy Timișoara, Eftimie Murgu Square, No. 2, 300041 Timisoara, Romania.
Larisa BoraDepartment of Pharmacognosy-Phytotherapy, "Victor Babeș" University of Medicine and Pharmacy Timișoara, Eftimie Murgu Square, No. 2, 300041 Timisoara, Romania.ORCID 0000-0002-9367-4770 Sorin Dan ChiriacUniversity Clinic of Surgery III, Faculty of Medicine, "Victor Babeș" University of Medicine and Pharmacy Timișoara, Eftimie Murgu Square, No. 2, 300041 Timisoara, Romania.ORCID 0000-0003-1704-5865 Ștefana AvramDepartment of Pharmacognosy-Phytotherapy, "Victor Babeș" University of Medicine and Pharmacy Timișoara, Eftimie Murgu Square, No. 2, 300041 Timisoara, Romania.ORCID 0000-0002-4824-6769 Daliana MindaDepartment of Pharmacognosy-Phytotherapy, "Victor Babeș" University of Medicine and Pharmacy Timișoara, Eftimie Murgu Square, No. 2, 300041 Timisoara, Romania.ORCID 0000-0002-7138-4908 Jevgeņija LugiņinaInstitute of Chemistry and Chemical Technology, Faculty of Natural Sciences and Technology, Riga Technical University, Paula Valdena Str. 3, LV-1048 Riga, Latvia.ORCID 0000-0001-8147-9698 Vladislavs KroškinsInstitute of Chemistry and Chemical Technology, Faculty of Natural Sciences and Technology, Riga Technical University, Paula Valdena Str. 3, LV-1048 Riga, Latvia.ORCID 0009-0008-1749-0890 Māris TurksInstitute of Chemistry and Chemical Technology, Faculty of Natural Sciences and Technology, Riga Technical University, Paula Valdena Str. 3, LV-1048 Riga, Latvia.ORCID 0000-0001-5227-0369 Ioana Zinuca Magyari-PavelDepartment of Pharmacognosy-Phytotherapy, "Victor Babeș" University of Medicine and Pharmacy Timișoara, Eftimie Murgu Square, No. 2, 300041 Timisoara, Romania.ORCID 0000-0002-2223-5228 Ștefania DinuDepartment of Pedodontics, Faculty of Dental Medicine, "Victor Babeș" University of Medicine and Pharmacy Timișoara, No. 9, Revolutiei Bv., 300041 Timisoara, Romania.ORCID 0000-0002-4351-7726 Cristina Adriana DeheleanDepartment of Toxicology, Drug Industry, Management and Legislation, Faculty of Pharmacy, "Victor Babeș" University of Medicine and Pharmacy Timișoara, Eftimie Murgu Square, No. 2, 300041 Timisoara, Romania.
Corina DanciuDepartment of Pharmacognosy-Phytotherapy, "Victor Babeș" University of Medicine and Pharmacy Timișoara, Eftimie Murgu Square, No. 2, 300041 Timisoara, Romania.ORCID 0000-0001-5999-1214 Funding
Romanian Ministry of Education and Research CNCS-UEFISCDI, Project number PN-III-P1-1.1-PD-2019-1231, within PNCDI III, PD 206/2020
6 · The paper itselfAbstract
In view of the concerning rise in the incidence of cancer, natural products are a valuable source for the development of novel therapies. Among phytochemicals, the pentacyclic triterpenoids betulinic (BA), ursolic (UA), and oleanolic (OA) acids, as well as their 3-oxo-derivatives, have attracted considerable attention because of their significant anticancer potential. However, their clinical use is restricted by poor bioavailability, highlighting the need for obtaining semisynthetic derivatives with optimized pharmacokinetic and pharmacodynamic profiles. This study examined the biological effects of twelve new semisynthetic triterpenic and 3-oxo-triterpenic acid derivatives with methylphosphonate moieties of type C(17)-C(O)OCH
Indexed as
betulinic acidmelanoma cell linemethylphosphonate moietiesoleanolic acidursolic acid
Identifiers
PMID41465825
PMCPMC12734932
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