ArticleLife (Basel, Switzerland)2025
Changes in Cortisol Awakening Response During 10 Days of High-Intensity Cycling Exercise.
Article in Life (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Previous studies suggest that the cortisol awakening response (CAR) shows a biphasic pattern-either an increase or a blunting-in response to exercise involving overload, potentially reflecting physiological adaptation. However, its response to continuous high-intensity exercise under controlled experimental conditions has not been sufficiently investigated. This pilot case series examined daily CAR changes during a 10-day high-intensity cycling protocol (20 min/day at 80% of maximal oxygen uptake [V˙O2max]) in two healthy male participants. The CAR increased during Days 1-4 and returned to baseline levels from Day 5 onward, showing similar trends in acute physiological responses. V˙O2max and/or maximum workload improved following the intervention. These findings support the methodological feasibility of longitudinal CAR monitoring during short-term high-intensity exercise under controlled experimental conditions and suggest that CAR may be a promising non-invasive biomarker for assessing short-term physiological adaptation.
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