ArticleLife (Basel, Switzerland)2025
Standardized and Quantitative ICG Perfusion Assessment: Feasibility and Reproducibility in a Multicentre Setting.
Eline Feitsma, Hugo Schouw, Tim Hoffman, Sam van Dijk, Wido Heeman, Jasper Vonk, Floris Tange, Jan Koetje, Liesbeth Jansen, Abbey Schepers and 6 more
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In one paragraphArticle in Life (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 · Who and what moneyAuthors and funding
16 authors.
Eline FeitsmaDepartment of Surgery, University Medical Centre Groningen, 9713 GZ Groningen, The Netherlands.ORCID 0000-0001-8626-0863 Hugo SchouwDepartment of Surgery, University Medical Centre Groningen, 9713 GZ Groningen, The Netherlands.ORCID 0000-0002-8996-4353 Tim HoffmanDepartment of Surgery, University Medical Centre Groningen, 9713 GZ Groningen, The Netherlands.ORCID 0000-0001-8176-8190 Sam van DijkDepartment of Surgical Oncology and Gastrointestinal Surgery, Erasmus MC Cancer Institute, University Medical Centre Rotterdam, 3015 GD Rotterdam, The Netherlands.ORCID 0000-0002-4745-7978 Wido HeemanDepartment of Surgery, University Medical Centre Groningen, 9713 GZ Groningen, The Netherlands.ORCID 0000-0003-0784-1876 Jasper VonkDepartment of Nuclear Medicine and Molecular Imaging, University Medical Centre Groningen, 9713 GZ Groningen, The Netherlands.ORCID 0000-0003-1620-5505 Floris TangeDepartment of Surgery, Leiden University Medical Centre, 2333 ZA Leiden, The Netherlands.ORCID 0000-0001-7274-2802 Liesbeth JansenDepartment of Surgery, University Medical Centre Groningen, 9713 GZ Groningen, The Netherlands.ORCID 0000-0002-5363-132X Abbey SchepersDepartment of Surgery, Leiden University Medical Centre, 2333 ZA Leiden, The Netherlands.ORCID 0000-0003-0504-3491 Tessa van GinhovenDepartment of Surgical Oncology and Gastrointestinal Surgery, Erasmus MC Cancer Institute, University Medical Centre Rotterdam, 3015 GD Rotterdam, The Netherlands.ORCID 0000-0002-9365-4892 Wendy KelderDepartment of Surgery, University Medical Centre Groningen, 9713 GZ Groningen, The Netherlands.ORCID 0000-0002-5536-8940 Gooitzen van DamDepartment of Nuclear Medicine and Molecular Imaging, University Medical Centre Groningen, 9713 GZ Groningen, The Netherlands.ORCID 0000-0002-7248-8696 Wiktor SzymanskiDepartment of Medicinal Chemistry, Photopharmacology and Imaging, Groningen Research Institute of Pharmacy, University of Groningen, 9713 AV Groningen, The Netherlands.ORCID 0000-0002-9754-9248 Milou NoltesDepartment of Surgery, University Medical Centre Groningen, 9713 GZ Groningen, The Netherlands.ORCID 0000-0003-4520-9249 Schelto KruijffDepartment of Surgery, University Medical Centre Groningen, 9713 GZ Groningen, The Netherlands.ORCID 0000-0002-5151-7320 Funding
No grant is acknowledged in the PubMed record.
6 · The paper itselfAbstract
Indocyanine green near-infrared fluorescence (ICG-NIRF) imaging is widely used to assess tissue perfusion, yet its subjective interpretation limits correlation with postoperative parathyroid function. To address this, the Workflow model for ICG-angiography integrating Standardization and Quantification (WISQ) was developed. This exploratory prospective multicenter study evaluated the reproducibility of WISQ in adults undergoing total thyroidectomy at two Dutch university centres. Patients with contraindications to ICG or prior neck surgery were excluded. Intraoperative imaging used standardized camera settings with blood volume-adjusted ICG dosing, and perfusion curves were analyzed using predefined regions of interest. Eighty patients were included. Significant inter-centre variability was observed in maximum fluorescence intensity, inflow slope, and outflow slope (
Indexed as
hypoparathyroidismICG Angiographyindocyanine greenNear-Infrared Fluorescenceparathyroid perfusionperfusion quantificationstandardizationthyroidectomy
Identifiers
PMID41465807
PMCPMC12734919
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