Evidence map›Paper›PMID 41465799›Full record

ArticleLife (Basel, Switzerland)2025

Chitosan Protects Peripheral Nerves Against Damage Induced by Diabetes Mellitus.

Anca-Maria Țucă, Carmen Albu, Alexandra Nicoleta Preda, Alexandra Oltea Dan, Elena-Anca Târtea, Andrei Greșiță, Denisa Floriana Vasilica Pîrșcoveanu, Veronica Sfredel, Smaranda Ioana Mitran, Georgică Târtea

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Article in Life (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Anca-Maria ȚucăExperimental Research Centre for Normal and Pathological Aging, University of Medicine and Pharmacy of Craiova, 2 Petru Rares Street, 200349 Craiova, Romania.
Carmen AlbuDepartment of Neurology, University of Medicine and Pharmacy of Craiova, 2 Petru Rares St., 200349 Craiova, Romania.ORCID 0009-0008-9603-5860
Alexandra Nicoleta PredaExperimental Research Centre for Normal and Pathological Aging, University of Medicine and Pharmacy of Craiova, 2 Petru Rares Street, 200349 Craiova, Romania.
Alexandra Oltea DanExperimental Research Centre for Normal and Pathological Aging, University of Medicine and Pharmacy of Craiova, 2 Petru Rares Street, 200349 Craiova, Romania.
Elena-Anca TârteaDepartment of Neurology, University of Medicine and Pharmacy of Craiova, 2 Petru Rares St., 200349 Craiova, Romania.
Andrei GreșițăExperimental Research Centre for Normal and Pathological Aging, University of Medicine and Pharmacy of Craiova, 2 Petru Rares Street, 200349 Craiova, Romania.
Denisa Floriana Vasilica PîrșcoveanuDepartment of Neurology, University of Medicine and Pharmacy of Craiova, 2 Petru Rares St., 200349 Craiova, Romania.
Veronica SfredelExperimental Research Centre for Normal and Pathological Aging, University of Medicine and Pharmacy of Craiova, 2 Petru Rares Street, 200349 Craiova, Romania.
Smaranda Ioana MitranExperimental Research Centre for Normal and Pathological Aging, University of Medicine and Pharmacy of Craiova, 2 Petru Rares Street, 200349 Craiova, Romania.ORCID 0000-0002-4458-2298
Georgică TârteaExperimental Research Centre for Normal and Pathological Aging, University of Medicine and Pharmacy of Craiova, 2 Petru Rares Street, 200349 Craiova, Romania.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDiabetic peripheral neuropathy (DPN) is one of the most common and debilitating complications of diabetes mellitus, for which current therapies do not prevent nerve degeneration. Chitosan, a biocompatible polysaccharide with antioxidant, anti-inflammatory, and lipid-lowering properties, may exert direct neuroprotective effects. This study evaluated the impact of oral administration of chitosan on peripheral nerve function and structure in a murine model of streptozotocin (STZ)-induced diabetes.

methodsMale C57BL/6 mice were divided into three groups: Sham, untreated diabetics (T1DM) and diabetics treated with chitosan (150 mg/kg/day, 12 weeks). Metabolic, behavioral (Open Field), nociceptive (Von Frey, Tail-Flick), electrophysiological (compound motor action potential-CMAP) and histological (intraepidermal nerve fiber density-IENF) parameters were analyzed.

resultsChitosan did not significantly modify blood glucose (

conclusionsOral administration of chitosan confers functional and structural neuroprotection in STZ-induced diabetic neuropathy despite persistent hyperglycemia.

Indexed as

chitosandiabetes mellitusdiabetic peripheral neuropathy

Identifiers

PMID41465799
PMCPMC12734295

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.