In one paragraphArticle in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
10 authors.
Mikel M Arbulo-EchevarriaDepartment of Biomedicine, Biotechnology and Public Health, Universidad de Cádiz, 11002 Cádiz, Spain.ORCID 0000-0002-1453-6880 Luis M Fernandez-AguilarDepartment of Biomedicine, Biotechnology and Public Health, Universidad de Cádiz, 11002 Cádiz, Spain.ORCID 0000-0002-3050-3907 Elke KurzKennedy Institute of Rheumatology, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford OX1 7FY, UK.ORCID 0000-0002-9446-4943 Inmaculada Vico-BarrancoDepartment of Biomedicine, Biotechnology and Public Health, Universidad de Cádiz, 11002 Cádiz, Spain.ORCID 0000-0002-4279-7244 Raquel Muñoz-FernándezDepartment of Biomedicine, Biotechnology and Public Health, Universidad de Cádiz, 11002 Cádiz, Spain.ORCID 0009-0004-1179-1714 Isaac Narbona-SánchezDepartment of Biomedicine, Biotechnology and Public Health, Universidad de Cádiz, 11002 Cádiz, Spain.ORCID 0000-0003-1696-267X Manuel CarrascoDepartment of Biomedicine, Biotechnology and Public Health, Universidad de Cádiz, 11002 Cádiz, Spain.
Bernard MalissenCentre d'Immunologie de Marseille-Luminy (CIML), Aix Marseille Université, Institut National de la Santé et de la Recherche Médicale (INSERM), Centre National de la Recherche Scientifique (CNRS), 13009 Marseille, France.ORCID 0000-0003-1340-9342 Michael L DustinKennedy Institute of Rheumatology, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford OX1 7FY, UK.ORCID 0000-0003-4983-6389 Enrique AguadoDepartment of Biomedicine, Biotechnology and Public Health, Universidad de Cádiz, 11002 Cádiz, Spain.ORCID 0000-0002-7232-2661 Funding
Agencia Estatal de Investigación PID2020-113943RB-I00Biomedical Research and Innovation Institute of Cadiz LI19/I14NCO15Chinese Academy of Medical Sciences (CAMS) Innovation Fund for Medical Science (CIFMS) 2024-I2M-2-001-1Consejería de Universidad, Investigación e Innovación PY20_01297European Research Council 787300Kennedy Trust for Rheumatology Research MSP 12 13 21Salvador de Madariaga Mobility Program from the Spanish Ministry of Science PRX17/00327Universidad de Cádiz PR2022-037Wellcome Trust PRF 100262Z/12/ZZhongyuan Academician Fund from Henan Province C24185
6 · The paper itselfAbstract
Activation through the T cell receptor (TCR) initiates a signaling cascade in T cells that induces extensive molecular and cellular changes. The adaptor protein Linker for Activation of T cells (LAT) plays an essential role in transducing activation and regulatory signals downstream of the TCR. Phosphorylation of LAT tyrosine residues recruits multiple signaling proteins, leading to the assembly of the LAT signalosome, which is crucial for relaying signals that regulate T cell development and function. We previously showed that substitution of a negatively charged amino acid segment preceding the fifth tyrosine residue of LAT (Tyr127 in humans or Tyr132 in mouse LAT) enhances some early TCR signaling events, whereas downstream responses, such as Ca
Indexed as
Adaptor Proteins, Signal TransducingMembrane ProteinsMutationReceptors, Antigen, T-Cell, gamma-deltaT-LymphocytesAnimalsCell DifferentiationMiceMice, Inbred C57BLMice, KnockoutSignal TransductionAdaptor Proteins, Signal TransducingLat protein, mouseMembrane ProteinsReceptors, Antigen, T-Cell, gamma-deltaLATsignalingTCRγδ T cell
Identifiers
PMID41465611
PMCPMC12734389
What OpenQuestion holds
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LicenceCC BY
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