Evidence map›Paper›PMID 41465564›Full record

ArticleInternational journal of molecular sciences2025

Mechanistic Fingerprints from Chloride to Iodide: Halide vs. Ammonia Release in Platinum Anticancer Complexes.

Lorenzo Chiaverini, Luca Famlonga, Davide Piroddu, Matteo Pacini, Riccardo Di Leo, Emma Baglini, Damiano Cirri, Tiziano Marzo, Diego La Mendola, Alessandro Pratesi and 5 more

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Lorenzo ChiaveriniDepartment of Pharmacy, University of Pisa, Via Bonanno Pisano 6, 56126 Pisa, Italy.ORCID 0000-0003-4857-9819
Luca FamlongaDepartment of Pharmacy, University of Pisa, Via Bonanno Pisano 6, 56126 Pisa, Italy.ORCID 0009-0007-6990-7179
Davide PirodduDepartment of Chemical, Physical, Mathematical and Natural Sciences, University of Sassari, 07100 Sassari, Italy.
Matteo PaciniDepartment of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Via Savi 10, 56126 Pisa, Italy.
Riccardo Di LeoNational Council of Research (CNR), Institute of Clinical Physiology, 56124 Pisa, Italy.
Emma BagliniNational Council of Research (CNR), Institute of Clinical Physiology, 56124 Pisa, Italy.ORCID 0000-0002-8378-4052
Damiano CirriDepartment of Chemistry and Industrial Chemistry (DCCI), University of Pisa, Via G. Moruzzi, 13, 56124 Pisa, Italy.ORCID 0000-0001-9175-9562
Tiziano MarzoDepartment of Pharmacy, University of Pisa, Via Bonanno Pisano 6, 56126 Pisa, Italy.ORCID 0000-0002-2567-3637
Diego La MendolaDepartment of Pharmacy, University of Pisa, Via Bonanno Pisano 6, 56126 Pisa, Italy.ORCID 0000-0002-4193-7612
Alessandro PratesiDepartment of Chemistry and Industrial Chemistry (DCCI), University of Pisa, Via G. Moruzzi, 13, 56124 Pisa, Italy.ORCID 0000-0002-9553-9943
Paola FerrariDepartment of Oncology, Pisa University Hospital, Via Roma 57, 56126 Pisa, Italy.ORCID 0000-0003-2983-9726
Andrea NicoliniDepartment of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Via Savi 10, 56126 Pisa, Italy.ORCID 0000-0002-5178-9510
Alessandro ZucchiDepartment of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Via Savi 10, 56126 Pisa, Italy.ORCID 0000-0003-2252-4297
Alessandro MarroneDepartment of Pharmacy, University "G d'Annunzio" Chieti-Pescara, Via dei Vestini 31, 66100 Chieti, Italy.ORCID 0000-0002-8311-8172
Iogann TolbatovDepartment of Chemical, Physical, Mathematical and Natural Sciences, University of Sassari, 07100 Sassari, Italy.ORCID 0000-0001-9700-5331

Funding

Ministero dell'università e della ricerca 2022ALJRPLUniversity of Pisa SPARK-2025
6 · The paper itself

Abstract

Platinum-based drugs play a pivotal role in contemporary cancer treatment, but their therapeutic utility is often limited by acquired resistance. The diiodido analog, cis-[PtI

Indexed as

AmmoniaAntineoplastic AgentsChloridesIodidesOrganoplatinum CompoundsCisplatinDensity Functional TheoryHalogensHumansMagnetic Resonance SpectroscopyThermodynamicsAmmoniaAntineoplastic AgentsChloridesCisplatinHalogensIodidesOrganoplatinum Compoundscancercisplatin analogDFTNMRplatinum complexes

Identifiers

PMID41465564
PMCPMC12733153

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.