Evidence map›Paper›PMID 41465532›Full record

ArticleInternational journal of molecular sciences2025

Elacridar Reverses P-gp-Mediated Drug Resistance in Ovarian Cancer Cells in 2D and 3D Culture Models.

Piotr Stasiak, Justyna Sopel, Julia Maria Lipowicz, Agnieszka Anna Rawłuszko-Wieczorek, Karolina Sterzyńska, Jan Korbecki, Radosław Januchowski

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Piotr StasiakInstitute of Biological Sciences, University of Zielona Góra, 65-417 Zielona Góra, Poland.ORCID 0000-0002-7276-4494
Justyna SopelInstitute of Health Sciences, Collegium Medicum, University of Zielona Góra, 65-417 Zielona Góra, Poland.ORCID 0009-0004-4569-5464
Julia Maria LipowiczDepartment of Histology and Embryology, Doctoral School, Poznan University of Medical Sciences, 61-701 Poznań, Poland.
Agnieszka Anna Rawłuszko-WieczorekDepartment of Histology and Embryology, Poznan University of Medical Sciences, 61-701 Poznań, Poland.ORCID 0000-0003-4721-9010
Karolina SterzyńskaDepartment of Histology and Embryology, Poznan University of Medical Sciences, 61-701 Poznań, Poland.ORCID 0000-0002-3936-7534
Jan KorbeckiInstitute of Health Sciences, Collegium Medicum, University of Zielona Góra, 65-417 Zielona Góra, Poland.ORCID 0000-0003-1642-1259
Radosław JanuchowskiInstitute of Health Sciences, Collegium Medicum, University of Zielona Góra, 65-417 Zielona Góra, Poland.ORCID 0000-0001-7286-0657

Funding

National Science Centre 2021/41/B/NZ5/01128
6 · The paper itself

Abstract

Multidrug resistance (MDR) remains a major obstacle in the treatment of ovarian cancer. MDR is often mediated by the overexpression of ATP-binding cassette (ABC) transporters, such as P-glycoprotein (P-gp) and Breast Cancer Resistance Protein (BCRP). In this study, we evaluated the ability of elacridar, a dual P-gp and BCRP inhibitor, to overcome MDR in W1, an ovarian cancer cell line sensitive to Paclitaxel (PAC) and its PAC-resistant variants. Cells were cultured under both two-dimensional (2D) and three-dimensional (3D) conditions to account for differences in tumor-like microenvironments. The

Indexed as

AcridinesATP Binding Cassette Transporter, Subfamily B, Member 1Drug Resistance, MultipleDrug Resistance, NeoplasmOvarian NeoplasmsTetrahydroisoquinolinesAntineoplastic AgentsATP Binding Cassette Transporter, Subfamily BATP Binding Cassette Transporter, Subfamily G, Member 2Cell Culture TechniquesCell Line, TumorCell SurvivalFemaleHumansNeoplasm ProteinsPaclitaxelABCG2 protein, humanAcridinesAntineoplastic AgentsATP Binding Cassette Transporter, Subfamily BATP Binding Cassette Transporter, Subfamily B, Member 1ATP Binding Cassette Transporter, Subfamily G, Member 2ElacridarNeoplasm ProteinsPaclitaxelTetrahydroisoquinolines3D cell culture modelelacridarmultidrug resistanceovarian cancerP-glycoprotein (P-gp)

Identifiers

PMID41465532
PMCPMC12733000

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.