Evidence map›Paper›PMID 41465525›Full record

ArticleInternational journal of molecular sciences2025

Protective Effects of Arecoline on LPS-Induced Neuroinflammation in BV2 Microglial Cells.

Xiangfei Zhang, Jingwen Cui, Jing Sun, Bei Fan, Fengzhong Wang, Cong Lu

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Xiangfei ZhangInstitute of Food Science and Technology, Chinese Academy of Agricultural Sciences, Beijing 100193, China.
Jingwen CuiInstitute of Food Science and Technology, Chinese Academy of Agricultural Sciences, Beijing 100193, China.
Jing SunInstitute of Food Science and Technology, Chinese Academy of Agricultural Sciences, Beijing 100193, China.ORCID 0000-0002-3569-7093
Bei FanInstitute of Food Science and Technology, Chinese Academy of Agricultural Sciences, Beijing 100193, China.
Fengzhong WangInstitute of Food Science and Technology, Chinese Academy of Agricultural Sciences, Beijing 100193, China.
Cong LuInstitute of Food Science and Technology, Chinese Academy of Agricultural Sciences, Beijing 100193, China.

Funding

BeiFan, CongLu 2022YFD1600303BeiFan, CongLu CAAS-ASTIP-2025-IFST
6 · The paper itself

Abstract

Natural alkaloids derived from edible and medicinal plants have recently gained attention as bioactive molecules capable of modulating neuroinflammatory processes. Arecoline, the major alkaloid constituent of

Indexed as

ArecolineLipopolysaccharidesMicrogliaNeuroinflammatory DiseasesNeuroprotective AgentsAnimalsCell LineCell SurvivalCytokinesInflammationMiceNF-kappa BNitric OxidePhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktSignal TransductionArecolineCytokinesLipopolysaccharidesNeuroprotective AgentsNF-kappa BNitric OxidePhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktToll-Like Receptor 4Areca catechuarecolinebioactive alkaloidBV2 microgliamicroglial activationneuroinflammationsignaling pathways

Identifiers

PMID41465525
PMCPMC12733217

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.