ArticleInternational journal of molecular sciences2025
Comparative Effects of Two Hyaluronic Acid-Based Formulations on Cellular Repair Mechanisms in Human Keratinocytes.
Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Hyaluronic Acid-Based Biomaterials for Soft Tissue Repair and Wound Healing: Clinical Evidence and Emerging Applications.Gels (Basel, Switzerland) · 2026Review
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Hyaluronic acid formulations are widely used in aesthetic and regenerative medicine, yet molecular weight-dependent effects on cellular repair remain incompletely characterized. This study investigated two hyaluronic acid formulations-low- and medium-high-molecular-weight ranges with trehalose (LMHMW-HA; 200-400 and 1200-1500 kDa) and high-molecular-weight range (HMW-HA; 1800-2600 kDa)-on keratinocyte repair using an in vitro scratch assay. Human keratinocyte monolayers were treated with various concentrations, and repair dynamics were monitored over 48 h through microscopy and quantitative inter-edge distance analysis. Both formulations significantly enhanced gap closure compared to controls without cytotoxic effects. LMHMW-HA promoted gradual closure over 48 h with increased cellular density, indicating sustained proliferation and migration. HMW-HA induced faster closure at approximately 30 h, accompanied by transient pericellular swelling consistent with hydration-mediated edge approximation. These findings indicate that LMHMW-HA and HMW-HA promote repair through distinct patterns: LMHMW-HA was associated with gradual closure and increased cellular density consistent with proliferation-driven repair, while HMW-HA induced rapid closure with transient pericellular swelling consistent with hydration-mediated effects. These preliminary observations suggest complementary repair mechanisms and provide a foundation for future mechanistic investigations. The molecular weight-tailored approach combining HA with trehalose offers therapeutic potential for aesthetic and regenerative medicine applications requiring enhanced tissue repair.
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