Elevated

Helen F Dietmar, Ella P Dennis, Francesca M Johnson de Sousa Brito, Louise N Reynard, David A Young, Michael D Briggs

Abstract read

In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Helen F DietmarBiosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne NE1 3BZ, UK.ORCID 0000-0001-8409-3221

Ella P DennisBiosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne NE1 3BZ, UK.ORCID 0000-0002-3076-703X

Francesca M Johnson de Sousa BritoBiosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne NE1 3BZ, UK.

Louise N ReynardBiosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne NE1 3BZ, UK.ORCID 0000-0002-6613-1797

David A YoungBiosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne NE1 3BZ, UK.

Michael D BriggsBiosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne NE1 3BZ, UK.

Funding

UK Research and Innovation MR/X001873/1

6 · The paper itself

Abstract

The intracellular retention of misfolded extracellular matrix proteins is a common disease mechanism in various rare skeletal diseases. This discovery has driven the study of ER stress and the unfolded protein response (UPR) as a promising therapeutic target in several skeletal dysplasias. In the case of

Indexed as

AchondroplasiaCartilage Oligomeric Matrix ProteinMatrix Metalloproteinase 9OsteochondrodysplasiasBiomarkersChondrocytesHumansMatrilin ProteinsMutationUnfolded Protein ResponseBiomarkersCartilage Oligomeric Matrix ProteinMatrilin ProteinsMatrix Metalloproteinase 9MMP9 protein, humanTSP5 protein, humanbiomarkerendoplasmic reticulum/cell stressmatrix metalloproteinaseprotein misfoldingskeletal dysplasia

Identifiers

PMID41465495

DOI10.3390/ijms262412070

PMCPMC12732529

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.