Evidence map›Paper›PMID 41465482›Full record

ArticleInternational journal of molecular sciences2025

Temperature-Dependent Recombinase-Based Genetic Circuits.

Marc Gonzalez-Colell, Mariana Gomes Del Castillo, Marta Palau Gauthier, Javier Macia

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Marc Gonzalez-ColellSynthetic Biology for Biomedical Applications Lab, Department of Medicine and Life Sciences, Universitat Pompeu Fabra, Biomedical Research Park, 08003 Barcelona, Spain.
Mariana Gomes Del CastilloSynthetic Biology for Biomedical Applications Lab, Department of Medicine and Life Sciences, Universitat Pompeu Fabra, Biomedical Research Park, 08003 Barcelona, Spain.
Marta Palau GauthierSynthetic Biology for Biomedical Applications Lab, Department of Medicine and Life Sciences, Universitat Pompeu Fabra, Biomedical Research Park, 08003 Barcelona, Spain.ORCID 0000-0002-4567-9868
Javier MaciaSynthetic Biology for Biomedical Applications Lab, Department of Medicine and Life Sciences, Universitat Pompeu Fabra, Biomedical Research Park, 08003 Barcelona, Spain.ORCID 0000-0002-6705-5554

Funding

Agencia Española de Investigacion PID2023-151156NB-I00/MICIUN/AEI/10.13039/501100011033/FEDER
6 · The paper itself

Abstract

Temperature offers a simple yet powerful signal to program cellular behavior. Here, we engineered and characterized a set of temperature-dependent genetic circuits that integrate RNA thermometers with site-specific DNA recombinases to achieve precise, irreversible control of gene expression. Using the serine recombinase Bxb1 placed under the control of the

Indexed as

DNA NucleotidyltransferasesGene Regulatory NetworksRecombinasesTemperatureGene Expression Regulation, BacterialPromoter Regions, GeneticDNA NucleotidyltransferasesRecombinasesSite-specific recombinasecellular patterningcircuitsrecombinaseregulationRNA thermometerssynthetic biologytemperature-dependent

Identifiers

PMID41465482
PMCPMC12733206

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.