Evidence map›Paper›PMID 41465443›Full record

ArticleInternational journal of molecular sciences2025

Recombinant RGD-Apoptins Decrease Human Melanoma Cell Viability.

Dmitriy Shirokov, Daria Lepekhina, Valentin Manuvera, Margarita Bogomiakova, Aleksandra Strokach, Anastasia Kazakova, Georgij Arapidi, Vassili Lazarev

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Dmitriy ShirokovLopukhin Federal Research and Clinical Center of Physical-Chemical Medicine of Federal Medical Biological Agency, Moscow 119435, Russia.ORCID 0000-0001-6080-3348
Daria LepekhinaLopukhin Federal Research and Clinical Center of Physical-Chemical Medicine of Federal Medical Biological Agency, Moscow 119435, Russia.
Valentin ManuveraLopukhin Federal Research and Clinical Center of Physical-Chemical Medicine of Federal Medical Biological Agency, Moscow 119435, Russia.ORCID 0000-0002-2471-0563
Margarita BogomiakovaLopukhin Federal Research and Clinical Center of Physical-Chemical Medicine of Federal Medical Biological Agency, Moscow 119435, Russia.ORCID 0000-0003-0945-6891
Aleksandra StrokachLopukhin Federal Research and Clinical Center of Physical-Chemical Medicine of Federal Medical Biological Agency, Moscow 119435, Russia.ORCID 0009-0009-9470-7640
Anastasia KazakovaLopukhin Federal Research and Clinical Center of Physical-Chemical Medicine of Federal Medical Biological Agency, Moscow 119435, Russia.
Georgij ArapidiLopukhin Federal Research and Clinical Center of Physical-Chemical Medicine of Federal Medical Biological Agency, Moscow 119435, Russia.ORCID 0000-0003-2323-1859
Vassili LazarevLopukhin Federal Research and Clinical Center of Physical-Chemical Medicine of Federal Medical Biological Agency, Moscow 119435, Russia.

Funding

Russian Science Foundation 24-25-00344
6 · The paper itself

Abstract

Cutaneous melanoma is an extremely dangerous tumor disease with poor prognosis at advanced stages. Accounting for a small percentage of all skin tumors, malignant melanoma leads the mortality rate in this group of cancers. Clearly, the search for new drugs and therapeutic approaches for the treatment of cutaneous melanoma is a highly pressing issue in modern medicine. In this study, novel recombinant proteins with anti-melanoma activity, called RGD-apoptins, were produced in an

Indexed as

Capsid ProteinsMelanomaOligopeptidesRecombinant Fusion ProteinsSkin NeoplasmsApoptosisCell Line, TumorCell SurvivalHumansMelanocytesRecombinant Proteinsarginyl-glycyl-aspartic acidCapsid ProteinsOligopeptidesRecombinant Fusion ProteinsRecombinant Proteinsapoptinapoptosisdual-specificity oncolytic proteinsmelanomaMeWoRGD peptidestherapeutic recombinant proteinstranscriptomicsαVβ3 integrins

Identifiers

PMID41465443
PMCPMC12732338

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.