Evidence map›Paper›PMID 41465442›Full record

ArticleInternational journal of molecular sciences2025

Neuroplastic Effects Induced by Hypercapnic Hypoxia in Rat Focal Ischemic Stroke Are Driven via BDNF and VEGF Signaling.

Pavel P Tregub, Pavel A Chekulaev, Georgy M Zembatov, Eugenia D Namiot, Michael A Ignatyuk, Dmitrii A Atiakshin, Arseniy K Berdnikov, Zaripat Sh Manasova, Peter F Litvitskiy, Vladimir P Kulikov

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Trial
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Pavel P TregubBrain Science Institute, Russian Center of Neurology and Neurosciences, 125367 Moscow, Russia.ORCID 0000-0002-3650-6121
Pavel A ChekulaevBrain Science Institute, Russian Center of Neurology and Neurosciences, 125367 Moscow, Russia.
Georgy M ZembatovBrain Science Institute, Russian Center of Neurology and Neurosciences, 125367 Moscow, Russia.
Eugenia D NamiotBrain Science Institute, Russian Center of Neurology and Neurosciences, 125367 Moscow, Russia.
Michael A IgnatyukScientific and Educational Resource Center "Innovative Technologies of Immunophenotyping, Digital Spatial Profiling and Ultrastructural Analysis", RUDN University, 117198 Moscow, Russia.
Dmitrii A AtiakshinScientific and Educational Resource Center "Innovative Technologies of Immunophenotyping, Digital Spatial Profiling and Ultrastructural Analysis", RUDN University, 117198 Moscow, Russia.ORCID 0000-0002-8347-4556
Arseniy K BerdnikovBrain Science Institute, Russian Center of Neurology and Neurosciences, 125367 Moscow, Russia.
Zaripat Sh ManasovaDepartment of Pathophysiology, I.M. Sechenov First Moscow State Medical University, 119991 Moscow, Russia.
Peter F LitvitskiyDepartment of Pathophysiology, I.M. Sechenov First Moscow State Medical University, 119991 Moscow, Russia.
Vladimir P KulikovDepartment of Ultrasound and Functional Diagnostics, Altay State Medical University, 656040 Barnaul, Russia.ORCID 0000-0003-4869-5465

Funding

Russian Science Foundation 25-25-00101
6 · The paper itself

Abstract

In this study, the neurorehabilitation potential of combined and isolated intermittent hypercapnia and hypoxia exposure was evaluated following photochemically induced cerebral thrombosis in rats. Particular attention was given to the roles of possible neuroplasticity mechanisms mediated by VEGF and BDNF, as well as the potential of hypercapnic-hypoxic interventions to synergistically amplify the therapeutic effects of pharmacological neuroprotectants during recovery. A total of 50 male Wistar rats were randomly assigned to five equal groups (

Indexed as

Brain-Derived Neurotrophic FactorHypercapniaHypoxiaIschemic StrokeNeuronal PlasticityVascular Endothelial Growth Factor AAnimalsDisease Models, AnimalMaleRatsRats, WistarSignal TransductionBdnf protein, ratBrain-Derived Neurotrophic FactorVascular Endothelial Growth Factor Avascular endothelial growth factor A, ratBDNFhypercapnic hypoxiaischemic strokeneuroplasticityneurorehabilitationVEGF

Identifiers

PMID41465442
PMCPMC12733143

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.