Evidence map›Paper›PMID 41465427›Full record

ArticleInternational journal of molecular sciences2025

Cortical White and Grey Matter Volume Differences Associated with Plasma Cytokine and Chemokine Levels in PLWH in Cape Town.

Vurayai Ruhanya, Susan Engelbrecht, Monray E Williams, Robert H Paul, Justen Manasa, George Nyandoro, John A Joska, Soraya Seedat, Richard Helmuth Glashoff

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Vurayai RuhanyaDivision of Medical Virology, Department of Pathology, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town 8000, South Africa.
Susan EngelbrechtDivision of Medical Virology, Department of Pathology, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town 8000, South Africa.ORCID 0000-0002-1318-5994
Monray E WilliamsBiomedical and Molecular Metabolism Research (BioMMet), North-West University, Potchefstroom 2531, South Africa.ORCID 0000-0001-6698-8451
Robert H PaulDepartment of Psychology and Behavioral Neuroscience, University of Missouri-St Louis, 1 University Blvd, St. Louis, MO 63121, USA.
Justen ManasaMedical Microbiology Unit, Department of Laboratory Diagnostic and Investigative Science, Faculty of Medicine and Health Sciences, University of Zimbabwe, Avondale, Harare PO Box A178, Zimbabwe.
George NyandoroMedical Microbiology Unit, Department of Laboratory Diagnostic and Investigative Science, Faculty of Medicine and Health Sciences, University of Zimbabwe, Avondale, Harare PO Box A178, Zimbabwe.ORCID 0000-0001-8991-0948
John A JoskaMRC Unit of Anxiety & Stress Disorders, Department of Psychiatry & Mental Health, University of Cape Town, Cape Town 8000, South Africa.ORCID 0000-0003-4260-1181
Soraya SeedatMRC Unit of Anxiety & Stress Disorders, Department of Psychiatry, University of Stellenbosch, Cape Town 8000, South Africa.
Richard Helmuth GlashoffDivision of Medical Microbiology, Stellenbosch University, Cape Town 8000, South Africa.

Funding

Advanced Training in Community Based Research; training in Bio-informatics, Drug Resistance and PathogenesisD43TW011326 · FIC · BIOMEDICAL RESEARCH & TRAINING INSTITUTE · PI MUNYATI, SHUNGU · 2020 to 2024
$1.6M
D43 D43TW011236FIC NIH HHS D43 TW011326
6 · The paper itself

Abstract

HIV infection is accompanied by production of pro-inflammatory cytokines, which are regarded as critical in neuronal damage, leading to brain dysfunction. To develop diagnostic tools and therapeutic interventions, we need to measure CNS response to immune activation, hence the need to identify specific cytokine biomarkers that are associated with brain damage in HIV infection. This cross-sectional retrospective study applied Magnetic Resonance Imaging (MRI) for brain volumetric measurements and high-throughput Luminex-based immunoassays to quantify plasma cytokine and chemokine concentrations. We then used generalized linear models and Partial Least Square Regression models to evaluate the association between brain volume and plasma cytokines in predominantly treatment-naïve participants with HIV. After adjusting for clinical and demographic variables, we observed that higher MCP-1 (

Indexed as

ChemokinesCytokinesGray MatterHIV InfectionsWhite MatterAdultBiomarkersCross-Sectional StudiesFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedRetrospective StudiesSouth AfricaBiomarkersChemokinesCytokineschemokinescognitive impairmentcytokinesinflammationLuminexMRI

Identifiers

PMID41465427
PMCPMC12733071

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.